Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species

dc.creatorBarros, André de Lima
dc.creatorLima, Emilly J. S. P. de
dc.creatorFaria, Jéssica V.
dc.creatorAcho, Leonard R. D.
dc.creatorLima, Emerson S.
dc.creatorBezerra, Daniel P.
dc.creatorSoares, Elzalina R.
dc.creatorLima, Bruna R. de
dc.creatorCosta, Emmanoel V.
dc.creatorPinheiro, Maria Lúcia B.
dc.creatorBataglion, Giovana A.
dc.creatorSilva, Felipe M. A. da
dc.creatorCardozo, Nállaret M. Dávila
dc.creatorGonçalves, José F. C.
dc.creatorKoolen, Hector H. F.
dc.date2023-01-25T18:08:48Z
dc.date2023-01-25T18:08:48Z
dc.date2022
dc.date.accessioned2023-09-26T20:18:54Z
dc.date.available2023-09-26T20:18:54Z
dc.identifierBARROS, André de Lima et al. Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species. Chemistry, v. 4, p. 1-18, 2022
dc.identifier2624-8549
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/56616
dc.identifier10.3390/chemistry4040081
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854018
dc.descriptionFundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
dc.descriptionEssential oils from Amazonian species are gaining increasing interest worldwide due to their medicinal and cosmetic applications; however, the relation among the chemical constituents and their biological properties are not well explored. Therefore, the present research aims to obtain an understanding of the bioactivity of chemical compounds in the essential oils of plants from the Annonaceae family (Bocageopsis pleiosperma, Onychopetalum amazonicum, Unonopsis duckei, U. floribunda, U. rufescens, U. stipitata, U. guatterioides, Duguetia flagellaris and Xylopia benthamii). By means of gas chromatography coupled to mass spectrometry, in vitro cytotoxic and anti-lipase assays, principal component analysis and molecular docking, it was possible to establish the main compounds that may be responsible for the cytotoxic effect of O. amazonicum and B. pleiosperma. Moreover, the anti-lipase potential of D. flagellaris was also established, as well as its composition related to the activity. Thus, by the employed strategy, allo-aromadendrene, cryptomerione, δ-cadinene and β-bisabolene were suggested as plausible cytotoxic agents against cancer cell lines, and dehydroaromadendrene, spathulenol and elemol, against lipase. The present study provides significant information on the chemical profile and bioactivity studies of Amazon Annonaceae aromatic plants
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectAnnonaceae
dc.subjectÓleos essenciais
dc.subjectBocageopsis
dc.subjectOnychopetalum
dc.subjectLipase
dc.subjectCâncer
dc.subjectAnnonaceae
dc.subjectEssential oils
dc.subjectBocageopsis
dc.subjectOnychopetalum
dc.subjectLipase
dc.subjectCancer
dc.subjectAnnonaceae
dc.subjectÓleos Voláteis
dc.subjectLipase
dc.subjectNeoplasias
dc.titleCytotoxicity and lipase inhibition of essential oils from amazon annonaceae species
dc.typeArticle


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