dc.creatorPrudêncio, Ana Paula Aguiar
dc.creatorFonseca, Danielle Cristina
dc.creatorMachado, Natasha Mendonça
dc.creatorAlves, Juliana Tepedino Martins
dc.creatorSala, Priscila
dc.creatorFernandes, Gabriel R
dc.creatorTorrinhas, Raquel Susana
dc.creatorWaitzberg, Dan Linetzky
dc.date2023-04-24T17:31:34Z
dc.date2023-04-24T17:31:34Z
dc.date2023
dc.date.accessioned2023-09-26T20:18:40Z
dc.date.available2023-09-26T20:18:40Z
dc.identifierPRUDÊNCIO, Ana Paula Aguiar et al. Red Meat Intake, Indole-3-Acetate, and Dorea longicatena Together Affect Insulin Resistance after Gastric Bypass. Nutrients, v. 15, n. 5, 1185, 2023. doi: 10.3390/nu15051185.
dc.identifier2072-6643
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/57942
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853919
dc.descriptionRoux-en-Y Gastric bypass (RYGB) promotes improvement in type 2 diabetes (T2D) shortly after surgery, with metabolic mechanisms yet to be elucidated. This study aimed to investigate the relationship between food intake, tryptophan metabolism, and gut microbiota on the glycemic control of obese T2D women after RYGB surgery. Twenty T2D women who underwent RYGB were evaluated before and three months after surgery. Food intake data were obtained by a seven-day food record and a food frequency questionnaire. Tryptophan metabolites were determined by untargeted metabolomic analysis, and the gut microbiota was determined by 16S rRNA sequencing. The glycemic outcomes were fasting blood glucose, HbA1C, HOMA-IR, and HOMA-beta. Linear regression models were applied to assess the associations between the changes in food intake, tryptophan metabolism, and gut microbiota on glycemic control after RYGB. All variables changed after RYGB (p < 0.05), except for tryptophan intake. Jointly, the variation in red meat intake, plasma indole-3-acetate, and Dorea longicatena was associated with postoperative HOMA-IR {R2 0.80, R2 adj 0.74; p < 0.01}. Red meat intake decreased three months after bariatric surgery while indole-3-acetate and Dorea longicatena increased in the same period. These combined variables were associated with better insulin resistance in T2D women after RYGB.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI Publishing
dc.rightsopen access
dc.subjectGut microbiota
dc.subjectRoux-en-Y Gastric bypass
dc.subjectfood intake
dc.subjectindole-3-acetate
dc.subjectinsulin resistance
dc.subjectmetabolomics
dc.subjectred meat
dc.subjecttryptophan metabolism
dc.subjecttype 2 diabetes
dc.titleRed Meat Intake, Indole-3-Acetate, and Dorea longicatena Together Affect Insulin Resistance after Gastric Bypass
dc.typeArticle


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