Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10.

dc.creatorLima, Milena da Silva
dc.creatorQuintans Junior, Lucindo José
dc.creatorSantana, Wagno Alcântara
dc.creatorKaneto, Carla Martins
dc.creatorSoares, Milena Botelho Pereira
dc.creatorVillarreal, Cristiane Flora
dc.date2014-10-08T18:03:30Z
dc.date2014-10-08T18:03:30Z
dc.date2013
dc.date.accessioned2023-09-26T20:18:34Z
dc.date.available2023-09-26T20:18:34Z
dc.identifierLIMA, M. S. et al. Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10. European Journal of Pharmacology, v. 699, n. 1-3, p. 112-117, 2013.
dc.identifier1879-0712
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8552
dc.identifier10.1016/j.ejphar.2012.11.040
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853882
dc.descriptionCarvacrol,aphenolicmonoterpene,hasbeenreportedtopossessanti-inflammatoryproperties. However,themechanismsinvolvedinitspharmacologicalpropertiesarecurrentlynotwellunder- stood. Inthepresentstudy,thecontributionofcytokinemodulationtotheanti-inflammatoryeffectsof carvacrolwasinvestigatedinaclassicalinflammationmodel:thecompleteFreund’sadjuvant(CFA)- inducedpawinflammationinmice.Thepawedemawasmeasuredusingaplesthismometer.Pawtissue was removed2haftertheinflammatorystimulustodeterminethelevelsofprostaglandinE2 (PGE2) by enzyme immunoassay,thelevelsofinterleukin-1 b (IL-1b), tumornecrosisfactor-a (TNF-a), and interleukin-10(IL-10)byELISAorthemRNAexpressionofcyclooxygenase-2(COX-2),IL-1b, TNF-a, and IL-10 byreal-timePCR.Administrationofcarvacrolproducedanti-inflammatoryeffectsagainstCFA- inducedinflammationinmice.Treatmentofmicewithcarvacrolat50and100mg/kgattenuatedthe paw edemaandreducedtheIL-1b and PGE2, butnotTNF-a, locallevels.Similarly,carvacrol(100mg/kg) reducedtheCOX-2andIL-1b mRNA expression.ThelevelsofIL-10,ananti-inflammatorycytokine,and the IL-10mRNAexpressionintheinflamedpawwereenhancedbycarvacrol.Inaddition,thetreatment with carvacroldidnotreducetheCFA-inducedpawedemainIL-10knockoutmice.Thepresentresults suggestthatcarvacrolcausesanti-inflammatoryeffectsbyreducingtheproductionofinflammatory mediators,suchasIL-1b and prostanoids,possiblythroughtheinductionofIL-10release.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier B.V
dc.rightsopen access
dc.subjectCarvacrol
dc.subjectAnti-inflammatory
dc.subjectCytokines
dc.subjectInterleukin-10
dc.subjectPGE2
dc.subjectAnti-Inflamatórios/farmacologia
dc.subjectInflamação/quimioterapia
dc.subjectInterleucina-10/metabolismo
dc.subjectMonoterpenos/farmacologia
dc.subjectAnimais
dc.subjectAnti-Inflamatórios/administração & dosagem
dc.subjectModelos Animais de Doenças
dc.subjectRelação Dose-Resposta a Droga
dc.subjectEdema/quimioterapia
dc.subjectRegulação da Expressão Gênica/efeitos de drogas
dc.subjectMediadores da Inflamação/metabolismo
dc.subjectMasculino
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos C57BL
dc.subjectMonoterpenos/administração & dosagem
dc.subjectReação em Cadeia da Polimerase em Tempo Real
dc.titleAnti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10.
dc.typeArticle


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