Association between developmental defects of enamel and celiac disease: A meta-analysis.

dc.creatorSouza, Débora Souto
dc.creatorSoares, Maria Eliza da Consolação
dc.creatorRezende, Vanessa Silva
dc.creatorDantas, Paulo César de Lacerda
dc.creatorGalvão, Endi Lanza
dc.creatorFalci, Saulo Gabriel Moreira
dc.date2018-03-09T12:26:40Z
dc.date2018-03-09T12:26:40Z
dc.date2018
dc.date.accessioned2023-09-26T20:18:33Z
dc.date.available2023-09-26T20:18:33Z
dc.identifierSOUZA, Débora Souto et al. Association between developmental defects of enamel and celiac disease: A meta-analysis. Arch Oral Biol. Mar., v. 87, p. 180-190, 2018
dc.identifier0003-9969
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25209
dc.identifier10.1016/j.archoralbio.2017.12.025
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853871
dc.descriptionObjectives: Studies have observed the presence of extra-intestinal manifestations of celiac disease (CD), including involvement of the oral cavity, such that developmental defects of enamel (DDE) occur. Thus, the aim of this review was to access the polled prevalence of DDE in individuals with CD, and to establish the strength of the association between these two variables. Methods: To carry out the systematic review, four electronic databases and the Grey Literature were searched, complemented by a manual search of reference lists within the selected articles. Two pairs of independent reviewers selected the articles, and perform the data extractions and bias risk assessment Studies evaluating the presence of DDE in individuals with CD as well as in healthy individuals and which performed the DDE diagnosis by direct visualization of tooth enamel changes and the CD diagnosis were included. Meta-analyses were performed using the software R. Results: Of 557 studies, 45 were selected for review, encompassing 2840 patients. The prevalence of DDE in people with CD was 50% (95% CI 0.44–0.57, I2 = 88%). In a general analysis, it was observed that patients with CD had a significantly higher prevalence of enamel defects compared to healthy people (RR: 2.31, 95% CI: 1.71–3.12, I2 = 98%). Only developmental defects of enamel diagnosed using Aine’s method were associated with the disease (RR: 3.30, 95% CI 2.39–4.56, I2 = 75%). In a sensitivity analysis involving the deciduous, mixed and permanent dentitions, only individuals with deciduous dentition were observed to have association with the disease (RR: 2.34, 95% CI 1.25–4.39, I2 = 39%). Conclusions: Patients with enamel developmental defects should be screened for the possibility of their having celiac disease.
dc.description2023-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectdoença celíaca
dc.subjectCeliac sprue
dc.subjectDental enamel
dc.subjectEnamel hypoplasia
dc.subjectEpidemiology
dc.titleAssociation between developmental defects of enamel and celiac disease: A meta-analysis.
dc.typeArticle


Este ítem pertenece a la siguiente institución