Prevalence of the bla (SHV) gene in Klebsiella pneumoniae isolates obtained from hospital and community infections and from the microbiota of healthy individuals in Recife, Brazil

dc.creatorVeras, Dyana Leal
dc.creatorAlves, Luiz Carlos
dc.creatorBrayner, Fábio André
dc.creatorGuedes, Duschinka Ribeiro Duarte
dc.creatorMaciel, Maria Amélia Vieira
dc.creatorRocha, Cíntia Renata Costa
dc.creatorLopes, Ana Catarina de Souza
dc.date2018-04-23T13:07:07Z
dc.date2018-04-23T13:07:07Z
dc.date2011
dc.date.accessioned2023-09-26T20:18:22Z
dc.date.available2023-09-26T20:18:22Z
dc.identifierVERAS, D. L. et al. Prevalence of the bla (SHV) gene in Klebsiella pneumoniae isolates obtained from hospital and community infections and from the microbiota of healthy individuals in Recife, Brazil. Current Microbiology, v. 62, n. 5, p. 1610–1616, maio 2011.
dc.identifier1432-0991
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/26025
dc.identifier10.1007/s00284-011-9899-z
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853817
dc.descriptionEste estudo foi financiado pela FACEPE (Fundação de Amparo à Pesquisa do Estado de Pernambuco).
dc.descriptionThe aim of this study was to determine the prevalence of the bla (SHV) gene in Klebsiella pneumoniae isolates from hospital and community infections and from the normal microbiota of healthy individuals in Recife, PE, Brazil. Fifty-two K. pneumoniae isolates were analyzed regarding the presence of the bla (SHV) gene, using PCR, and eight isolates were analyzed by DNA sequencing. This gene was detected in 16 isolates from hospital infections, four from community infections, and nine from the normal microbiota. This was the first study to find the bla (SHV) gene in K. pneumoniae isolates from the normal microbiota. Through DNA sequencing of eight K. pneumoniae isolates from hospital and community infections, with a resistance phenotype indicative of extended-spectrum β-lactamase production, a new SHV variant named SHV-122 was found. We also detected the presence of bla (SHV-1), bla (SHV-11), bla (SHV-28), and bla (SHV-108). The results show that in Recife, Brazil, K. pneumoniae isolates that presented resistance to oxyimino-β-lactams had high prevalence and diversity of the bla (SHV) gene. We also conclude that there was a high presence of the bla (SHV) gene among isolates from the normal microbiota of healthy individuals.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectCefotaxima
dc.subjectCeftazidima
dc.subjectAztreonam
dc.subjectDisco Difusão Teste
dc.subjectNormal Microbiota
dc.subjectCefotaxime
dc.subjectCeftazidime
dc.subjectAztreonam
dc.subjectDisk Diffusion Test
dc.subjectNormal Microbiota
dc.subjectAntibacterianos / farmacologia
dc.subjectProteínas Bacterianas / genética
dc.subjectProteínas Bacterianas / metabolismo
dc.subjectTécnicas de Tipagem Bacteriana
dc.subjectBrasil / epidemiologia
dc.subjectInfecções Comunitárias Adquiridas / epidemiologia
dc.subjectInfecções Comunitárias Adquiridas / microbiologia
dc.subjectInfecção Cruzada / epidemiologia
dc.subjectInfecção Cruzada / Microbiologia
dc.subjectResistência a Drogas Bacterianas
dc.subjectHumanos
dc.subjectInfecções por Klebsiella / epidemiologia
dc.subjectInfecções por Klebsiella / microbiologia
dc.subjectKlebsiella pneumoniae / efeitos de drogas
dc.subjectKlebsiella pneumoniae / enzimologia
dc.subjectKlebsiella pneumoniae / genética
dc.subjectKlebsiella pneumoniae / isolamento & purificação
dc.subjectTestes de Sensibilidade Microbiana
dc.subjectDados de Sequencia Molecular
dc.subjectBeta-lactamases / genética *
dc.subjectbeta-lactamases / metabolismo
dc.titlePrevalence of the bla (SHV) gene in Klebsiella pneumoniae isolates obtained from hospital and community infections and from the microbiota of healthy individuals in Recife, Brazil
dc.typeArticle


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