Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population

dc.creatorGrant, A. V.
dc.creatorAraujo, Maria Ilma Andrade Santos
dc.creatorPonte, Eduardo Vieira
dc.creatorOliveira, Ricardo Riccio
dc.creatorCruz, Alvaro Augusto Souza da
dc.creatorBarnes, K. C.
dc.creatorBeaty, Terri H.
dc.date2018-07-05T14:14:06Z
dc.date2018-07-05T14:14:06Z
dc.date2011
dc.date.accessioned2023-09-26T20:18:21Z
dc.date.available2023-09-26T20:18:21Z
dc.identifierGRANT, A. V. et al. Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population. Genes and Immunity, v. 12, p. 46–50, 2011.
dc.identifier1466-4879
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27309
dc.identifier10.1038/gene.2010.50
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853810
dc.descriptionOliveira, Ricardo Riccio. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
dc.descriptionGlaxo-Smith-Kline under the project WE445 entitled ‘Immunogenetics of Schistosomiasis and Asthma,’ and NIH grant # AI050024. KCB was supported in part by the Mary Beryl Patch Turnbull Scholar Program.
dc.descriptionInterleukin (IL)-10 is a regulatory cytokine of the helper T cell type 2 (TH2) pathway, which underlies both the host defense to helminthic infection and atopic diseases, including asthma. Although IL10 promoter polymorphisms are associated with increased atopy risk, IL10 variation has not been thoroughly explored in schistosomiasis-endemic populations. Three atopy-related IL10 promoter polymorphisms (rs1800896, rs1800871 and rs1800872), complemented by six tagging single-nucleotide polymorphisms (SNPs), were genotyped in 812 individuals in 318 nuclear families from a schistosomiasis-endemic area in Brazil. Associations between markers and total serum Immunoglobulin E (tIgE) levels, indicating non-specific activation of the TH2 pathway, and Schistosoma mansoni fecal egg counts, indicating burden of infection reflecting effectiveness of schistosomiasis host immunity, were performed using family-based transmission disequilibrium tests for quantitative traits (QTDTs). Alleles A, T and A at the three promoter SNPs rs1800896, rs1800871 and rs1800872 were associated with high tIgE levels in the same direction as in atopy populations (P=0.0008, 0.026 and 0.045), but not with egg counts. IL10 promoter polymorphisms appear to influence non-specific tIgE levels, but not schistosomiasis-specific immunity. The tagging SNP rs3024495 was associated with high S. mansoni egg counts (P=0.005), suggesting a novel locus in IL10 may influence clinically relevant burden of infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature Publishing Group
dc.rightsrestricted access
dc.subjectIgE
dc.subjectIL-10
dc.subjectEsquistossomose
dc.subjectAtopia
dc.subjectPolimorfismo promotor
dc.subjectSuscetibilidade genética
dc.subjectIgE
dc.subjectIL-10
dc.subjectSchistosomiasis
dc.subjectAtopy
dc.subjectPromoter polymorphism
dc.subjectGenetic susceptibility
dc.titlePolymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population
dc.typeArticle


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