Detection of uncommon rotavirus A strains P[8]G8 and P[4]G8 in the city of Rio de Janeiro, 2002

dc.creatorGómez, M. M.
dc.creatorVolotão, E. M.
dc.creatorMendonça, M. C. Lima de
dc.creatorTort, L. F. L.
dc.creatorSilva, M. F. M. da
dc.creatorLeite, J. P. G.
dc.date2018-03-20T14:12:24Z
dc.date2018-03-20T14:12:24Z
dc.date2010
dc.date.accessioned2023-09-26T20:17:55Z
dc.date.available2023-09-26T20:17:55Z
dc.identifierGÓMEZ, M. M. et al. Detection of Uncommon Rotavirus A Strains P[8]G8 and P[4]G8 in the City of Rio de Janeiro, 2002. Journal of Medical Virology, v. 82, p.1272–1276, 2010.
dc.identifier0146-6615
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25421
dc.identifier10.1002/jmv.21769
dc.identifier1096-9071
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853628
dc.descriptionGroup A rotaviruses (RV-A) are the major cause of gastroenteritis in infants and young children around the world. Each year RV-A causes approximately 11 million episodes of severe diarrhea, with an estimated of 611,000 deaths. Epidemiologic surveys have identified P[8]G1, P[4]G2, P[8]G3, P[8]G4, and P[8]G9 as the most common global genotypes associated with diarrhea in children up to 5-year old. Surveillance studies and documentation of RV-A G and P genotypes is necessary for a comprehensive evaluation of the evolution of new strains, and assessing the capability of vaccines to provide heterotypic protection. It is known that reassortments are the driving force for genetic diversity through sudden changes in RV-A genome. In this study, we identified two unusual P/G combinations, P[8]G8 and P[4]G8, occurring in Rio de Janeiro during 2002. Results obtained in this study suggest that P[8]G8 RV-A strain originated from a reassortment event that occurred between RV-A P[4]G8 and P[8]G9 strains circulating in Rio de Janeiro in the same year. G8 strains identified in this study, as well as G8 strains detected in Recife by Montenegro et al. [Montenegro et al. (2007) J Med Virol 79: 335-340], showed a close genetic relationship with strains from Africa, where this genotype have become prevalent.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectRotavirus A
dc.subjectGastroenterite
dc.subjectGenótipo G8
dc.subjectevolução do vírus
dc.subjectRio de Janeiro
dc.subjectrotavirus A
dc.subjectgastroenteritis
dc.subjectgenotype G8
dc.subjectreassortment
dc.subjectvirus evolution
dc.subjectRio de Janeiro
dc.titleDetection of uncommon rotavirus A strains P[8]G8 and P[4]G8 in the city of Rio de Janeiro, 2002
dc.typeArticle


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