BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells

dc.creatorThomaz, Amanda
dc.creatorJaeger, Mariane
dc.creatorBuendia, Marienela
dc.creatorBambini Junior, Victorio
dc.creatorGregianin, Lauro José
dc.creatorBrunetto, Algemir Lunardi
dc.creatorBrunetto, André T.
dc.creatorFarias, Caroline Brunetto de
dc.creatorRoesler, Rafael
dc.date2016-12-06T10:10:53Z
dc.date2016-12-06T10:10:53Z
dc.date2016
dc.date.accessioned2023-09-26T20:17:35Z
dc.date.available2023-09-26T20:17:35Z
dc.identifierTHOMAZ, Amanda; et al. BDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells. J. Mol Neurosci., v. 59, p.326–333., 2016.
dc.identifier0895-8696
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16429
dc.identifier10.1007/s12031-015-0689-0
dc.identifier1559-1166
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853496
dc.descriptionMedulloblastoma (MB) is the most common malignant pediatric brain tumor. Deregulation of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) signaling has been associated with increased proliferative capabilities, invasiveness, and chemoresistance in several types of cancer. However, the relevance of this pathway in MB remains unknown. Here, we show that the selective TrkB inhibitor N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide (ANA-12) markedly reduced the viability and survival of human cell lines representative of different MB molecular subgroups. These findings provide the first evidence supporting further investigation of TrkB inhibition as a potential novel strategy for MB treatment.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherHumana Press
dc.rightsrestricted access
dc.subjectCâncer infantil
dc.subjectTumor cerebral
dc.subjectMedulloblastoma
dc.subjectFator neurotrófico derivado do cérebro
dc.subjectTrkB
dc.subjectBrain-derived neurotrophic factor
dc.subjectMedulloblastoma
dc.subjectBrain tumor
dc.subjectChildhood cancer
dc.titleBDNF/TrkB Signaling as a Potential Novel Target in Pediatric Brain Tumors: Anticancer Activity of Selective TrkB Inhibition in Medulloblastoma Cells
dc.typeArticle


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