Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection

dc.creatorSouza, Robson da Paixão de
dc.creatorAraújo, Maria Ilma
dc.creatorLopes, Diego Mota
dc.creatorOliveira, Sérgio Costa
dc.creatorFernandes, Jamille Souza
dc.creatorJesus, Kelvin Edson M. de
dc.creatorCarvalho, Edgar M
dc.creatorOliveira, Ricardo Riccio
dc.creatorCardoso, Luciana Santos
dc.date2022-03-11T17:07:43Z
dc.date2022-03-11T17:07:43Z
dc.date2022
dc.date.accessioned2023-09-26T20:17:19Z
dc.date.available2023-09-26T20:17:19Z
dc.identifierSouza, Robson da Paixão de. et al. Profile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection. Parasitology Research, v. 121, p. 1-13, 2022.
dc.identifier1432-1955
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51689
dc.identifierdoi.org/10.1007/s00436-022-07435-5
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853396
dc.descriptionFundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
dc.descriptionSchistosoma mansoni still arouse great interest and controversy. Some authors demonstrate that resistance to infection is attributed to a mixed Th1 and Th2 response and resistance to reinfection after repeated treatments through mechanisms associated with the Th2 response. Through flow cytometry, the phenotypic characterization of B and T lymphocytes in individuals residing in endemic areas with low parasite loads over 10 years was evaluated for the first time in humans. In this study, individuals with low parasite loads for Schistosoma mansoni had a higher proportion of Th1 and Th2 cells. In addition, lymphocytes from these individuals showed a higher degree of expression of costimulatory molecules CD28 and CTLA-4 and regulatory molecules FoxP3 and IL-10, when compared to individuals with high parasite loads. Our data indicate that the control of the parasite load of S. mansoni must be associated with a Th1, Th2, and regulatory response, and that further studies are needed to elucidate the possibility of mechanisms associated with the hyporesponsiveness of lymphocytes from individuals with high parasite loads.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsopen access
dc.subjectEsquistossomose mansoni
dc.subjectLinfócitos T
dc.subjectLinfócitos B
dc.subjectEsquistossomose
dc.subjectSchistosomiasis mansoni
dc.subjectT-Lymphocytes
dc.subjectB-Lymphocytes
dc.subjectSchistosomiasis
dc.subjectEsquistosomiasis mansoni
dc.subjectLinfocitos T
dc.subjectLinfocitos B
dc.subjectEsquistosomiasis
dc.subjectSchistosomiase à Schistosoma manson
dc.subjectLymphocytes T
dc.subjectLymphocytes B
dc.subjectSchistosomiase
dc.titleProfile of T and B lymphocytes in individuals resistant to schistosoma mansoni infection
dc.typeArticle


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