Semaphorins and neuropilins: new players in the neuroendocrine control of the intrathymic T-cell migration in humans

dc.creatorCruz, Daniella Arêas Mendes da
dc.creatorLacerda, Leandra Linhares
dc.creatorSmaniotto, Salete
dc.creatorDardenne, Mireille
dc.creatorSavino, Wilson
dc.date2017-04-20T15:03:47Z
dc.date2017-04-20T15:03:47Z
dc.date2012
dc.date.accessioned2023-09-26T20:17:14Z
dc.date.available2023-09-26T20:17:14Z
dc.identifierCRUZ, Daniella Arêas Mendes da; et al. Semaphorins and neuropilins: new players in the neuroendocrine control of the intrathymic T-cell migration in humans. Esp. Psysiol, v.97, n.11, p.1146-1150, 2012.
dc.identifier0958-0670
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18596
dc.identifier10.1113/expphysiol.2011.061515
dc.identifier1469-445X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853358
dc.descriptionCell migration is a key event for proper intrathymic T-cell differentiation, and several ligand-receptor interactions contribute to the well-co ordinated movement of developing thymocytes within the thymic lobules. Herein we summarize recent data that place semaphorin 3A (Sema3A) and its receptor neuropilin 1 (NRP1) as further players in the physiological process of cell migration in the human thymus. These molecules, as well as class A plexins (necessary for the intracellular signalling transduction triggered by Sema3A-NRP1 ligation), are constitutively expressed by both developing thymocytes and components of the thymic microenvironment, including epithelial and dendritic cells. Functionally, Sema3A decreases the adhesion of human thymocytes on thymic epithelial cell monolayers and exerts per se a dose-dependent chemorepulsive effect on human thymocytes. Moreover, Sema3A inhibits chemoattractant migratory responses induced by other ligands, including fibronectin, laminin and CXCL12 (chemokine CXC motif ligand 12). These data should be placed in the context of the concept that migration of developing T cells is a multivectorial system, in which the resulting migration vector derives from a balance of several simultaneous and/or sequential ligand-receptor pair interactions. Accordingly, semaphorins and neuropilins can be considered as further players in the system.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectMigração intratímica de células T
dc.subjectControle neuroendócrino
dc.subjectNeuropilinas
dc.subjectSemaforinas
dc.subjectintrathymic T-cell migration
dc.subjectSemaphorins
dc.subjectneuropilins
dc.subjectneuroendocrine control
dc.titleSemaphorins and neuropilins: new players in the neuroendocrine control of the intrathymic T-cell migration in humans
dc.typeArticle


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