| dc.creator | Méio, Maria Dalva Barbosa Baker | |
| dc.creator | Moreira, Maria Elisabeth Lopes | |
| dc.creator | Sichieri, Rosely | |
| dc.creator | Moura, Aníbal Sanchez | |
| dc.date | 2015-05-06T12:05:13Z | |
| dc.date | 2015-05-06T12:05:13Z | |
| dc.date | 2009 | |
| dc.date.accessioned | 2023-09-26T20:16:59Z | |
| dc.date.available | 2023-09-26T20:16:59Z | |
| dc.identifier | MÉIO, Maria Dalva Barbosa Baker et al. Reduction of IGF-binding protein-3 as a potential marker of intra-uterine growth restriction. J. perinat. med., Berlin, v. 37, p. 689–693, 2009. | |
| dc.identifier | 0300-5577 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/10245 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8853263 | |
| dc.description | Background: Growth factor-binding proteins influence the growth of infants starting in utero. Adaptation of the fetus to an adverse uterine environment is associated with changes in the growth hormone-growth factor-insulin axis. Aims:To evaluate serum levels of IGF-I and IGFBP-3 in small and appropriate for gestational age newborn infants. Methods:Fifty-four newborn infants, small (SGA, ns28) or appropriate (AGA, ns26) for gestational age were matched by gestational age and sex. Blood was collect-ed on the first day of life, and anthropometric measure-ments were taken at birth. The serum levels of IGF-I and IGFBP-3 were compared, and correlated with the anthro-pometric measurements. Results:On the first day of life, mean serum IGFBP-3 levels were significantly lower in SGA babies and corre-lated with weight, length, head circumference, and pon-deral index (weight/length 3) (P-0.0001). In contrast, no associations were found between IGF-I serum levels and these anthropometric measurements. Conclusion:Our data show that SGA babies have sig-nificantly reduced IGFBP-3 concentrations at birth. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | De Gruyter | |
| dc.rights | restricted access | |
| dc.subject | IGF-Binding Protein-3 | |
| dc.subject | Insulin-Like Growth Factor-I | |
| dc.subject | Small for Gestational Age | |
| dc.subject | Proteína 1 de Ligação a Fator de Crescimento Semelhante à Insulina | |
| dc.subject | Idade Gestacional | |
| dc.title | Reduction of IGF-binding protein-3 as a potential marker of intra-uterine growth restriction | |
| dc.type | Article | |
