The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models

dc.creatorPaulino, Érica Tex
dc.creatorLima, Monique Ribeiro de
dc.creatorViçosa, Alessandra Lifsitch
dc.creatorSilva, Cleber Hooper da
dc.creatorSalomon, Claudio Javier
dc.creatorReal, Daniel Andrés
dc.creatorLeonardi, Dario
dc.creatorSilva, Clélia Christina Mello
dc.creatorMoraes Neto, Antonio Henrique Almeida de
dc.date2022-07-12T16:06:53Z
dc.date2022-07-12T16:06:53Z
dc.date2022
dc.date.accessioned2023-09-26T20:16:41Z
dc.date.available2023-09-26T20:16:41Z
dc.identifierPAULINO, Érica Tex et al. The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models. Frontiers in Public Health, v. 10, Article 848633, p. 1 - 10, May 2022.
dc.identifier2296-2565
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/53769
dc.identifier10.3389/fpubh.2022.848633
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853146
dc.descriptionSchistosomiasis is a widely distributed parasitic disease and one of the most important neglected tropical diseases globally, for which Praziquantel® (PZQ) is the only available treatment. In this context, tests with new PZQ formulations become relevant for disease control. This study evaluated the effects of PZQ treatment in the prepatent phase of schistosomiasis using two formulations: nanoencapsulated (PZQ-NANO) and active pharmaceutical ingredient (PZQ-API). Five experimental groups were established, for which the following serological parameters were evaluated: ALT, AST, ALP, and TP. Animals treated with PZQ-API at 15 and 30 days post-infection showed decreased eggs per gram of feces (EPG) compared to untreated infected animals. The same animals showed reductions of 63.6 and 65.1%, respectively, at 60 days post-infection. Animals treated with PZQ-NANO experienced no significant changes in EPG at any time of observation. Animals treated with either PZQ-API or PZQ-NANO had higher ALT and AST levels in the patent period (60 and 90 days post-infection). Treatment with PZQ, either API or NANO, at 15 days post-infection reduced AST, ALT, and TP levels. It is concluded that prepatent treatment with PZQ-API can reduce the parasite load of infected animals and that treatment at 15 days post-infection can prevent increased serum levels of ALT, AST, and TP.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectEsquistossomose
dc.subjectPraziquantel (PZQ)
dc.subjectInfecção pré-patente
dc.subjectSchistosoma mansoni (S. mansoni)
dc.subjectNanoencapsulação
dc.subjectSchistosomiasis
dc.subjectPraziquantel (PZQ),
dc.subjectPrepatent infection
dc.subjectSchistosoma mansoni (S. mansoni)
dc.subjectNanoencapsulated
dc.titleThe Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models
dc.typeArticle


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