Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis

dc.creatorReis, Alexandre Barbosa
dc.creatorMartins Filho, Olindo Assis
dc.creatorCarvalho, Andréa Teixeira de
dc.creatorCarvalho, Maria das Graças
dc.creatorMayrink, Wilson
dc.creatorSilva, João Carlos França da
dc.creatorGiunchetti, Rodolfo Cordeiro
dc.creatorGenaro, Odair
dc.creatorOliveira, Rodrigo Corrêa de
dc.date2013-08-09T13:22:14Z
dc.date2013-08-09T13:22:14Z
dc.date2005
dc.date.accessioned2023-09-26T20:16:37Z
dc.date.available2023-09-26T20:16:37Z
dc.identifierREIS, Alexandre Barbosa et al. Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. Res Vet Sci., v. 81, n. 1, p. 68-75, 2006.
dc.identifier0034-5288
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6777
dc.identifier10.1016/j.rvsc.2005.09.011
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853121
dc.descriptionWe have performed a detailed investigation in 40 dogs naturally infected with Leishmania infantum (syn. chagasi), subdivided into three groups: asymptomatic (AD = 12), oligosymptomatic (OD = 12) and symptomatic (SD = 16), based on their clinical features. Twenty non-infected dogs (CD) were included as control group. Serological analysis, performed by IFAT and ELISA, demonstrated higher antibodies titers in SD in comparison to the AD. A positive correlation was found between parasite density in the spleen and skin smears as well as the bone marrow parasitism with clinical status of the infection. We observed that the progression of the disease from asymptomatic to symptomatic clinical form was accompanied by intense parasitism in the bone marrow. It is likely that this led to the impaired biochemical/hematological status observed. Finally, we believe that the follow-up of these parameters could be a relevant approach to be used as markers during therapeutic and vaccine evaluations.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectCanine visceral leishmaniasis
dc.subjectLeishmania infantum(syn. chagasi)
dc.subjectParasite density
dc.subjectbiochemical/hematological status
dc.titleParasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis
dc.typeArticle


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