Degree of endothelium injury promotes fibroelastogenesis in experimental acute lung injury

dc.creatorChao, Mônica C. M.
dc.creatorGarcia, Cristiane S. N. B.
dc.creatorOliveira, Mariana B. G. de
dc.creatorSantos, Raquel S.
dc.creatorLucas, Isabela H.
dc.creatorSilva, Pedro L.
dc.creatorAbreu, Adriana Vieira de
dc.creatorFaria Neto, Hugo C. de Castro
dc.creatorParra-Cuentas, Edwin R.
dc.creatorCapelozzi, Vera L.
dc.creatorPelosi, Paolo
dc.creatorRocco, Patricia R. M.
dc.date2018-12-20T10:12:14Z
dc.date2018-12-20T10:12:14Z
dc.date2010
dc.date.accessioned2023-09-26T20:16:35Z
dc.date.available2023-09-26T20:16:35Z
dc.identifierCHAO, Mônica C. M. et al. Degree of endothelium injury promotes fibroelastogenesis in experimental acute lung injury. Respiratory Physiology & Neurobiology, v.173, p.179–188, 2010.
dc.identifier1569-9048
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/30705
dc.identifier10.1016/j.resp.2010.08.005
dc.identifier1878-1519
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853107
dc.descriptionWetested the hypothesis that at the early phase of acute lung injury (ALI) the degree of endothelium injury may predict lung parenchyma remodelling. For this purpose, two models of extrapulmonary ALI induced by Escherichia coli lipopolysaccharide (ALI-LPS) or cecal ligation and puncture (ALI-CLP) were developed in mice. At day 1, these models had similar degrees of lung mechanical compromise, epithelial damage, and intraperitoneal inflammation, but endothelial lesion was greater in ALI-CLP. A time course analysis revealed, at day 7: ALI-CLP had higher degrees of epithelial lesion, denudation of basement membrane, endothelial damage, elastic and collagen fibre content, neutrophils in bronchoalveolar lavage fluid (BALF), peritoneal fluid and blood, levels of interleukin-6, KC (murine analogue of IL-8), and transforming growth factor- in BALF. Conversely, the number of lung apoptotic cells was similar in both groups. In conclusion, the intensity of fibroelastogenesis was affected by endothelium injury in addition to the maintenance of epithelial damage and intraperitoneal inflammation.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectInflamação
dc.subjectFibra de colágeno
dc.subjectMecânica pulmonar
dc.subjectInflammation
dc.subjectCollagen fibre
dc.subjectLung mechanics
dc.subjectEndothelium
dc.subjectEpithelium
dc.subjectAcute lung injury
dc.subjectLesão Pulmonar Aguda
dc.subjectEpitélio
dc.subjectEndotélio
dc.titleDegree of endothelium injury promotes fibroelastogenesis in experimental acute lung injury
dc.typeArticle


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