C57BL/6 mice pretreated with alpha-tocopherol show a better outcome of trypanosoma cruzi infection with less tissue inflammation and fibrosis

dc.creatorSilva, Amanda C. O
dc.creatorBonfim, Maiara
dc.creatorFontes, Jonathan L. M
dc.creatorSantos, Washington L. C. dos
dc.creatorMengel, José
dc.creatorCardillo, Fabíola
dc.date2022-03-07T18:24:30Z
dc.date2022-03-07T18:24:30Z
dc.date2022
dc.date.accessioned2023-09-26T20:16:22Z
dc.date.available2023-09-26T20:16:22Z
dc.identifierSilva, Amanda C. O et al. C57BL/6 mice pretreated with alpha-tocopherol show a better outcome of trypanosoma cruzi infection with less tissue inflammation and fibrosis. Frontiers in Immunology, v. 13, p. 1-10, 2022.
dc.identifier1664-3224
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51599
dc.identifierdoi.org/10.3389/fimmu.2022.833560
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8853011
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). Fundação Octácilio Gualberto (FOG).
dc.descriptionChagas disease is accompanied by a multisystem inflammatory disorder that follows Trypanosoma cruzi infection. Alpha-tocopherol has been described as an antioxidant and a potential adjuvant to enhance immune responses to vaccines. Therefore, we have evaluated the immune response to T. cruzi infection upon alpha-tocopherol pre-administration. The results show that administration of alpha-tocopherol before the infection results in lower parasitemia and lower mortality of C57BL/6 mice infected with the Tulahuen T. cruzi strain. Alpha-tocopherol administration in normal C57BL/6 mice resulted in higher levels of IFN-γ production by T and NK cells before and after the infection with T. cruzi. More importantly, previous administration of alpha-tocopherol increased the production of IL-10 by T and myeloid suppressor cells and the formation of effector memory T cells while decreasing the expression of PD-1 on T cells. These results suggest that alpha-tocopherol may limit the appearance of dysfunctional T cells during the acute and early chronic phases of T. cruzi infection, contributing to control infection. In addition, alpha-tocopherol could diminish tissue inflammation and fibrosis in late acute disease. These results strongly suggest that alpha-tocopherol may be a helpful agent to be considered in Chagas disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectDoença de chagas
dc.subjectTrypanosoma cruzi
dc.subjectFibrose
dc.subjectImunomodulação
dc.subjectInterleucina-10
dc.subjectInterferon gama
dc.subjectInflamação
dc.subjectChagas disease
dc.subjectTrypanosoma cruzi
dc.subjectFibrosis
dc.subjectImmunomodulation
dc.subjectInterleukin-10
dc.subjectInterferon-gamma
dc.subjectInflammation
dc.subjectEnfermedad de chagas
dc.subjectTrypanosoma cruzi
dc.subjectFibrosis
dc.subjectInmunomodulación
dc.subjectInterleucina-10
dc.subjectInterferón gamma
dc.subjectInflamación
dc.subjectMaladie de chagas
dc.subjectTrypanosoma cruzi
dc.subjectFibrose
dc.subjectImmunomodulation
dc.subjectInterleukine-10
dc.subjectInterféron gamma
dc.subjectInflammation
dc.titleC57BL/6 mice pretreated with alpha-tocopherol show a better outcome of trypanosoma cruzi infection with less tissue inflammation and fibrosis
dc.typeArticle


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