Population-based differences in Schistosoma mansoni- and hepatitis C-induced disease.

dc.creatorBlanton, Ronald Edward
dc.creatorSalam, Ekram Abdel
dc.creatorKariuki, H. Curtis
dc.creatorMagak, Philip
dc.creatorSilva, Luciano Kalabric
dc.creatorMuchiri, Eric M.
dc.creatorThiongo, Fredrick
dc.creatorMeghid, Iman E.Abdel
dc.creatorButterworth, Anthony E
dc.creatorReis, Mitermayer Galvão dos
dc.creatorOuma, John H.
dc.date2014-04-30T17:46:05Z
dc.date2014-04-30T17:46:05Z
dc.date2002
dc.date.accessioned2023-09-26T20:16:16Z
dc.date.available2023-09-26T20:16:16Z
dc.identifierBLANTON R. E. et al. Population-based differences in Schistosoma mansoni- and hepatitis C-induced disease. Journal of Infectious Disease, v. 185, n. 11, p. 1644-1649, 2002.
dc.identifier0022-1899
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7562
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8852975
dc.descriptionTwo populations with differing histories of Schistosoma mansoni and hepatitis C infection were compared directly for severity of disease and extent of comorbidity. Demographic, parasitologic, and ultrasound surveys were conducted on 2038 Egyptians and on 2120 Kenyans. Hepatitis B and C serologies and transaminase levels were obtained from a subset at each site. Despite significantly lower prevalence and intensity of infection, Egyptians had a higher prevalence of severe schistosomal fibrosis than Kenyans (36.8% vs. 4.6%). Hepatitis C infection was 3 times more prevalent among Egyptians, and evidence of hepatocellular damage was significantly greater among Egyptians. There was no interaction between S. mansoni infection or disease and the prevalence or severity of hepatitis C. For both infections, the intensity or prevalence of infection was a poor predictor of morbidity. The prevalence of disease in the Egyptian population from different pathogens suggests a generalized susceptibility to inflammatory liver disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherInfectious Diseases Society of America
dc.rightsopen access
dc.subjectHepatite C/epidemiologia
dc.subjectVigilância da População
dc.subjectEsquistossomose mansoni/epidemiologia
dc.subjectÍndice de Gravidade de Doença
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectAnimais
dc.subjectCriança
dc.subjectComorbidade
dc.subjectEgito/epidemiologia
dc.subjectFeminino
dc.subjectHepacivirus/patogenicidade
dc.subjectHepatite C/ultrassonografia
dc.subjectHumanos
dc.subjectQuênia/epidemiologia
dc.subjectFígado/ultrassonografia
dc.subjectMasculino
dc.subjectSchistosoma mansoni/patogenicidade
dc.subjectMeia-Idade
dc.subjectEsquistossomose mansoni/ultrassonografia
dc.titlePopulation-based differences in Schistosoma mansoni- and hepatitis C-induced disease.
dc.typeArticle


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