Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina willd., a brazilian semiarid native woody plant

dc.creatorChacon, Daisy Sotero
dc.creatorSantos, Marlon Dias Mariano
dc.creatorBonilauri, Bernardo
dc.creatorVilasboa, Johnatan
dc.creatorCosta, Cibele Tesser da
dc.creatorSilva, Ivanice Bezerra da
dc.creatorTorres, Taffarel de Melo
dc.creatorAraújo, Thiago Ferreira de
dc.creatorRoque, Alan de Araújo
dc.creatorPilon, Alan Cesar
dc.creatorSelegatto, Denise Medeiros
dc.creatorFreire, Rafael Teixeira
dc.creatorReginaldo, Fernanda Priscila Santos
dc.creatorVoigt, Eduardo Luiz
dc.creatorZuanazzi, José Angelo Silveira
dc.creatorScortecci, Kátia Castanho
dc.creatorCavalheiro, Alberto José
dc.creatorLopes, Norberto Peporine
dc.creatorFerreira, Leandro De Santis
dc.creatorSantos, Leandro Vieira dos
dc.creatorFontes, Wagner
dc.creatorSousa, Marcelo Valle de
dc.creatorCarvalho, Paulo Costa
dc.creatorFett-Neto, Arthur Germano
dc.creatorGiordani, Raquel Brandt
dc.date2022-11-29T15:11:36Z
dc.date2022-11-29T15:11:36Z
dc.date2022
dc.date.accessioned2023-09-26T20:16:02Z
dc.date.available2023-09-26T20:16:02Z
dc.identifierCHACON, Daisy Sotero et al. Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina Willd., a Brazilian semiarid native woody plant. Front. Plant Sci, v. 13, n. 947558, p. 1–22, 2022.
dc.identifier1664-462X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/55824
dc.identifier10.3389/fpls.2022.947558
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8852881
dc.descriptionErythrina velutina is a Brazilian native tree of the Caatinga (a unique semiarid biome). It is widely used in traditional medicine showing anti-inflammatory and central nervous system modulating activities. The species is a rich source of specialized metabolites, mostly alkaloids and flavonoids. To date, genomic information, biosynthesis, and regulation of flavonoids remain unknown in this woody plant. As part of a larger ongoing research goal to better understand specialized metabolism in plants inhabiting the harsh condition of the Caatinga, the present study focused on this important class of bioactive phenolics. Leaves and seeds of plants growing in their natural habitat had their metabolic and proteomic profiles analyzed and integrated with transcriptome data. As a result, 96 metabolites (including 43 flavonoids) were annotated. Transcripts of the flavonoid pathway totaled 27, of which EvCHI, EvCHR, EvCHS, EvCYP75A and EvCYP75B1 were identified as putative main targets for modulating the accumulation of these metabolites. The highest correspondence of mRNA vs. protein was observed in the dierentially expressed transcripts. In addition, 394 candidate transcripts encoding for transcription factors distributed among the bHLH, ERF, and MYB families were annotated. Based on interaction network analyses, several putative genes of the flavonoid pathway and transcription factors were related, particularly TFs of the MYB family. Expression patterns of transcripts involved in flavonoid biosynthesis and those involved in responses to biotic and abiotic stresses were discussed in detail. Overall, these findings provide a base for the understanding of molecular and metabolic responses in this medicinally important species. Moreover, the identification of key regulatory targets for future studies aiming at bioactive metabolite production will be facilitated.
dc.formatapplication/pdf
dc.languagepor
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectErythrina velutin
dc.subjectCaatinga
dc.subjectFlavonoids
dc.subjectTranscriptome
dc.subjectPhenolic Compounds
dc.subjectPhytochemicals
dc.subjectFlavonoides
dc.subjectCompuestos Fenólicos
dc.subjectFitoquímicos
dc.subjectFlavonoïdes
dc.subjectComposés Phénoliques
dc.subjectComposés phytochimiques
dc.subjectErythrina
dc.subjectFlavonoides
dc.subjectTranscriptoma
dc.subjectCompostos Fenólicos
dc.subjectCompostos Fitoquímicos
dc.titleNon-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina willd., a brazilian semiarid native woody plant
dc.typeArticle


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