Oral and Intragastric: New Routes of Infection by Leishmania braziliensis and Leishmania infantum?

dc.creatorReimann, Mayra M.
dc.creatorSantos, Eduardo Caio Torres
dc.creatorSouza, Celeste S. F. de
dc.creatorAndrade Neto, Valter V.
dc.creatorJansen, Ana Maria
dc.creatorBrazil, Reginaldo P.
dc.creatorRoque, André Luiz R.
dc.date2022-06-23T18:38:28Z
dc.date2022-06-23T18:38:28Z
dc.date2022
dc.date.accessioned2023-09-26T20:15:34Z
dc.date.available2023-09-26T20:15:34Z
dc.identifierREIMANN, Mayra M. et al. Oral and Intragastric: New Routes of Infection by Leishmania braziliensis and Leishmania infantum?. Pathogens, v. 11, 688, p. 1 - 13, June 2022.
dc.identifier2076-0817
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/53454
dc.identifier10.3390/ pathogens11060688
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8852685
dc.descriptionAlthough Leishmania transmission in nature is associated with the bite of an infected sandfly vector, other possible transmission routes are speculated to occur, such as the oral route. We evaluated the possibility of infection by this route in golden hamsters (Mesocricetus auratus) using Leishmania braziliensis (Lb) and Leishmania infantum (Li). Hamsters were exposed to experimental oral or intragastrical infection with axenic promastigotes, besides oral ingestion of a suspension of cultivated macrophages infected with amastigotes, lesion-fed Lutzomyia longipalpis, skin lesion or infective spleen fragment. The parasite’s isolation, besides a positive PCR and IFAT, confirmed the intragastric infection by promastigote parasites. The oral ingestion of macrophages infected with L. braziliensis amastigotes was also infective. These results confirmed that Leishmania parasites could infect mammals by the intragastric route through the ingestion of promastigote forms (what can happen after a sandfly ingestion) and by the oral ingestion of infected macrophages (what can happen in nature in a predator–prey interaction). The better understanding of these alternative routes is essential to understand their transmission dynamics in nature. As far as we know, this is the first time that oral and intragastric Leishmania transmission has been experimentally demonstrated, constituting new infection routes, at least for L. infantum and L. braziliensis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectInfecção experimental
dc.subjectTransmissão oral
dc.subjectTransmissão intragástrica
dc.subjectHamsters
dc.subjectLeishmania braziliensis
dc.subjectLeishmania infantum
dc.subjectExperimental infection
dc.subjectOral transmission
dc.subjectIntragastric transmission
dc.subjectHamsters
dc.subjectLeishmania braziliensis
dc.subjectLeishmania infantum
dc.titleOral and Intragastric: New Routes of Infection by Leishmania braziliensis and Leishmania infantum?
dc.typeArticle


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