| dc.creator | Oliveira, Marcus Fernandes de | |
| dc.creator | Gandara, Ana Caroline Paiva | |
| dc.creator | Braga, Claudia M. S | |
| dc.creator | Silva, José Roberto da | |
| dc.creator | Dansa-Petretski, Marílvia | |
| dc.creator | Menezes, Diego | |
| dc.creator | Santos, Marcos André Vannier dos | |
| dc.creator | Oliveira, Pedro Lagerblad de | |
| dc.date | 2015-05-20T18:02:53Z | |
| dc.date | 2015-05-20T18:02:53Z | |
| dc.date | 2007 | |
| dc.date.accessioned | 2023-09-26T20:15:01Z | |
| dc.date.available | 2023-09-26T20:15:01Z | |
| dc.identifier | OLIVEIRA, M. F. de. Heme crystallization in the midgut of triatomine insects. Comparative Biochemistry and Physiology. C, Toxicology & Pharmacology, v. 146, n. 1-2, p. 168-174, 2007. | |
| dc.identifier | 1532-0456 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/10442 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8852459 | |
| dc.description | Hemozoin (Hz) is a heme crystal produced by several blood-feeding organisms in order to detoxify free heme released upon hemoglobin (Hb)
digestion. Here we show that heme crystallization also occurs in three species of triatomine insects. Ultraviolet-visible and infrared light
absorption spectra of insoluble pigments isolated from the midgut of three triatomine species Triatoma infestans, Dipetalogaster maximus and
Panstrongylus megistus indicated that all produce Hz. Morphological analysis of T. infestans and D. maximus midguts revealed the close
association of Hz crystals to perimicrovillar membranes and also as multicrystalline assemblies, forming nearly spherical structures. Heme
crystallization was promoted by isolated perimicrovillar membranes from all three species of triatomine bugs in vitro in heat-sensitive reactions. In
conclusion, the data presented here indicate that Hz formation is an ancestral adaptation of Triatominae to a blood-sucking habit and that the
presence of perimicrovillar membranes plays a central role in this process.
© 2007 Elsevier Inc. All rights reserved | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Elsevier | |
| dc.rights | open access | |
| dc.subject | Triatominae | |
| dc.subject | Heme | |
| dc.subject | Hemozoin | |
| dc.subject | Perimicrovillar membranes | |
| dc.subject | Midgut | |
| dc.subject | Heme | |
| dc.subject | Hemeproteínas | |
| dc.subject | Pigmentos Biológicos | |
| dc.subject | Triatominae | |
| dc.title | Heme crystallization in the midgut of triatomine insects | |
| dc.type | Article | |
