Apolipoprotein B genetic variability in brazilian indians

dc.creatorKaufman, Letícia
dc.creatorVargas, Andre Ferrao
dc.creatorCoimbra Junior, Carlos Everaldo Alvares
dc.creatorSantos, Ricardo Ventura
dc.creatorSalzano, Francisco Mauro
dc.creatorHutz, Mara Helena
dc.date2022-07-20T14:05:52Z
dc.date2022-07-20T14:05:52Z
dc.date1999
dc.date.accessioned2023-09-26T20:14:45Z
dc.date.available2023-09-26T20:14:45Z
dc.identifierKAUFMAN, Letícia et al. Apolipoprotein B genetic variability in brazilian indians. Human Biology, v. 71, n. 1, p. 87-98, Feb. 1999.
dc.identifier0018-7143
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/53892
dc.identifier1534-6617
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8852336
dc.descriptionThree apolipoprotein B restriction fragment length polymorphisms (RFLPs) (XbaI, MspI, and EcoRI) and the signal peptide insertion-deletion polymorphism were investigated using the polymerase chain reaction in 140 individuals from 5 Brazilian Indian tribes. All studied markers were polymorphic in this ethnic group. The insertion alíele 5' ßSP*29 at the signal peptide previously observed in Mexican Americans was detected in about 8% of the chromosomes of 2 tribes (Gavião and Zoró), therefore confirming the Amerindian origin of this allele. Negative linkage disequilibrium was observed between alleles at the signal peptide and the EcoRI polymorphism in all tribes. In 3 populations (Gavião, Suruí, and Zoró) a negative disequilibrium was also detected between the insertion-deletion signal peptide markers and the XbaI polymorphism. In the whole sample of Amerindians 14 of the 24 (58%) possible 4-marker extended haplotypes were identified, but only haplotype 2 (5'ßSP*24/*X+/*M+/*E + ) and haplotype 5 (5' ßSP*27/*X-/*M+/* E + ) were shared by all tribes. No associations between plasma lipid levels or body mass index and these polymorphisms were observed in this sample.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWayne State University Press
dc.rightsrestricted access
dc.subjectApolipoprotein B
dc.subjectPolymorphisms
dc.subjectAmerindians
dc.subjectBrazil
dc.titleApolipoprotein B genetic variability in brazilian indians
dc.typeArticle


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