Spontaneous telangiectatic osteosarcoma in a rhesus macaque (Macaca mulatta)

dc.creatorGoldschmidt, Beatriz
dc.creatorCalado, Monica I. Z.
dc.creatorResende, Felipe C.
dc.creatorCaldas, Rodrigo, M.
dc.creatorPinto, Laine
dc.creatorLopes, Claudia
dc.creatorFrança, F. G. O.
dc.creatorMeireles, Barbara
dc.creatorSouza, Igo
dc.date2018-09-27T19:02:59Z
dc.date2018-09-27T19:02:59Z
dc.date2017
dc.date.accessioned2023-09-26T20:14:25Z
dc.date.available2023-09-26T20:14:25Z
dc.identifierGOLDSCHMIDT, Beatriz et al. Spontaneous telangiectatic osteosarcoma in a rhesus macaque (Macaca mulatta). J. Med. Primatol., v. 46, p. 51–55, 2017.
dc.identifier10.1111/jmp.12254
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29132
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8852201
dc.descriptionOsteosarcoma (OS) is the most common type of bone cancer, especially in young. Telangiectatic osteosarcoma (TO) is a rare variant of OS, and hence, its occurrence, presentation, and prognosis are poorly understood. A 4-year-old female rhesus monkey presenting lameness and swelling was examined for a mass on the right humerus. Radiography revealed fracture and disorganized structure of bone tissue. Histopathological examination revealed malignant neoplasm composed of anaplastic osteoblasts, which invaded the bone marrow and surrounded blood-filled cysts in the epiphysis and diaphysis forming septa. Cytogenetic analysis showed aneuploid cells, supernumerary AgNORs, and a marker fragment. The neoplasm was diagnosed as TO. To our knowledge, the occurrence of TO and its cytogenetic analysis were reported for the first time in non-human primates.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsopen access
dc.subjectBone Cancer
dc.subjectChromosomes
dc.subjectNon-human Primate
dc.subjectOsteosarcoma
dc.titleSpontaneous telangiectatic osteosarcoma in a rhesus macaque (Macaca mulatta)
dc.typeArticle


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