The 2019-new coronavirus epidemic: Evidence for virus evolution

dc.creatorBenvenuto, Domenico
dc.creatorGiovanetti, Marta
dc.creatorCiccozzi, Alessandra
dc.creatorSpoto, Silvia
dc.creatorAngeletti, Silvia
dc.creatorCiccozzi, Massimo
dc.date2020-02-17T18:53:28Z
dc.date2020-02-17T18:53:28Z
dc.date2020
dc.date.accessioned2023-09-26T20:14:15Z
dc.date.available2023-09-26T20:14:15Z
dc.identifierBENVENUTO, Domenico et al. The 2019‐new coronavirus epidemic: Evidence for virus evolution. Journal of Medical Virology, p. 1-5, 2020.
dc.identifier0146-6615
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/40020
dc.identifier10.1002/jmv.25688
dc.identifier1096-9071
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8852155
dc.descriptionDevido a pandemia mundial do COVID-19, o artigo da revista foi liberado em acesso aberto durante o ano de 2020, visando divulgação e disseminação.
dc.descriptionEm decorrência da pandemia decretada pela OMS em 2020, o artigo encontra-se em acesso aberto.
dc.descriptionThere is a worldwide concern about the new coronavirus 2019-nCoV as a global public health threat. In this article, we provide a preliminary evolutionary and molecular epidemiological analysis of this new virus. A phylogenetic tree has been built using the 15 available whole genome sequences of 2019-nCoV, 12 whole genome sequences of 2019-nCoV, and 12 highly similar whole genome sequences available in gene bank (five from the severe acute respiratory syndrome, two from Middle East respiratory syndrome, and five from bat SARS-like coronavirus). Fast unconstrained Bayesian approximation analysis shows that the nucleocapsid and the spike glycoprotein have some sites under positive pressure, whereas homology modeling revealed some molecular and structural differences between the viruses. The phylogenetic tree showed that 2019-nCoV significantly clustered with bat SARS-like coronavirus sequence isolated in 2015, whereas structural analysis revealed mutation in Spike Glycoprotein and nucleocapsid protein. From these results, the new 2019-nCoV is distinct from SARS virus, probably trasmitted from bats after mutation conferring ability to infect humans.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.relationhttps://www.arca.fiocruz.br/handle/icict/40022
dc.rightsopen access
dc.subjectCoronavírus
dc.subjectEpidemiologia
dc.subjectCoronavirus
dc.subjectDesign macromolecular
dc.subjectCoronavirus
dc.subjectMacromolecular design
dc.subjectCoronavirus
dc.subjectEpidemiology
dc.subjectCOVID-19
dc.titleThe 2019-new coronavirus epidemic: Evidence for virus evolution
dc.typeArticle


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