High prevalence of enteric viruses associated with acute gastroenteritis in pediatric patients in a low-income area in Vitória, Southeastern Brazil

dc.creatorPratte-Santos, Rodrigo
dc.creatorMiagostovich, Marize Pereira
dc.creatorFumian, Tulio Machado
dc.creatorMaciel, Ethel Leonor
dc.creatorMartins, Sara Angelino
dc.creatorCassini, Sérvio Túlio
dc.creatorKeller, Regina
dc.date2019-05-02T11:17:03Z
dc.date2019-05-02T11:17:03Z
dc.date2019
dc.date.accessioned2023-09-26T20:14:14Z
dc.date.available2023-09-26T20:14:14Z
dc.identifierPRATTE-SANTOS, Rodrigo et al. High prevalence of enteric viruses associated with acute gastroenteritis in pediatric patients in a low‐income area in Vitória, Southeastern Brazil. Journal of Mmedical Virology, v. 91, p.744-750, 2019.
dc.identifier0146-6615
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/32899
dc.identifier10.1002/jmv.25392
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8852146
dc.descriptionAcute gastroenteritis (AGE) is a significant cause of child mortality worldwide. In Brazil, despite the reduction in infant mortality achieved in recent years, many children still die because of undiagnosed AGE. The prevalence, viral load, and circulating genotypes of rotavirus A (RVA), human adenovirus (HAdV), and norovirus GII (NoV GII) were investigated in children with AGE during 12 months in Vitoria, Espírito Santo, Southeastern Brazil. Enteric viruses were detected in stool samples, quantified by quantitative polymerase chain reaction, sequenced, and compared phylogenetically. The overall prevalence was 93.3% (125/134). Cases of single infection (41.8%) and mixed infection (51.5%) were observed; in 21.6% of cases, all the three viruses were detected. RVA had the highest number of copies in all infections. Phylogenetic analysis revealed predominantly the presence of RVA genotype G3, followed by G2 and G9. HAdV clustered within subgroup C, but some samples harbored subgroups A, D, or F. All sequenced NoV-positive samples clustered within the prevalent genotype GII.4. The high prevalence of RVA, HAdV, and NoV in diarrheal feces clarifies the etiology of AGE in this population, and the presence of RVA in vaccinated children reinforces the importance of monitoring programs to identify the causes of gastroenteritis and contribute to the reliability of diagnosis.
dc.description2022-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectRotavírus
dc.subjectGastroenterite aguda
dc.subjectVírus entéricos
dc.subjectNorovirus
dc.subjectAnálise filogenética
dc.subjectAdenovírus
dc.subjectAcute gastroenteritis
dc.subjectAdenovirus
dc.subjectEnteric viruses
dc.subjectNorovirus
dc.subjectPphylogenetic analysis
dc.subjectRotavirus
dc.titleHigh prevalence of enteric viruses associated with acute gastroenteritis in pediatric patients in a low-income area in Vitória, Southeastern Brazil
dc.typeArticle


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