The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMelo, Fernando L.
dc.creatorBenati, Fabricio J.
dc.creatorRoman, Walter Antonio
dc.creatorPalazzo de Mello, Joao Carlos
dc.creatorNozawa, Carlos
dc.creatorCarvalho Linhares, Rosa Elisa
dc.date2014-05-20T15:34:30Z
dc.date2016-10-25T18:10:57Z
dc.date2014-05-20T15:34:30Z
dc.date2016-10-25T18:10:57Z
dc.date2008-01-01
dc.date.accessioned2017-04-06T00:36:39Z
dc.date.available2017-04-06T00:36:39Z
dc.identifierMicrobiological Research. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 163, n. 2, p. 136-139, 2008.
dc.identifier0944-5013
dc.identifierhttp://hdl.handle.net/11449/42556
dc.identifierhttp://acervodigital.unesp.br/handle/11449/42556
dc.identifier10.1016/j.micres.2006.03.011
dc.identifierWOS:000254531400003
dc.identifierWOS000254531400003.pdf
dc.identifierhttp://dx.doi.org/10.1016/j.micres.2006.03.011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/885204
dc.descriptionWe investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian medicinal ptant. The NC was tested for its antiviral activity against poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BHV-1) by plaque reduction assay in cell culture. The NC showed a moderate antiviral activity against PV-1 and BHV-1 in HEp-2 celts, and the 50% inhibitory concentration (IC50) were 22.01 mu g/ml (selectivity index (SI) = 2.83) and 21.10 mu g/mi (SI = 2.95), respectivety. At the highest concentration of the drug (40 mu g/ml) a reduction of approximately 80% in plaque assay was observed for both viruses. The treatment of cells or virus prior to infection did not inhibit the replication of virus strains. (C) 2006 Elsevier GmbH. All rights reserved.
dc.languageeng
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.relationMicrobiological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHeteropteris ophrodisiaca
dc.subjectaliphatic nitro compound
dc.subjectpoliovirus
dc.subjectantiviral activity
dc.subjectbovine herpesvirus
dc.titleThe in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca
dc.typeOtro


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