Mesenchymal stromal cell therapy reduces lung inflammation and vascular remodeling and improves hemodynamics in experimental pulmonary arterial hypertension

dc.creatorMendonça, Lucas de
dc.creatorFelix, Nathane S.
dc.creatorBlanco, Natália G.
dc.creatorSilva, Jaqueline S. da
dc.creatorFerreira, Tatiana P.
dc.creatorAbreu, Soraia C.
dc.creatorCruz, Fernanda F.
dc.creatorRocha, Nazareth
dc.creatorSilva, Patrícia M.
dc.creatorMartins, Vanessa
dc.creatorCapelozzi, Vera L.
dc.creatorZapata-Sudo, Gizele
dc.creatorRocco, Patricia R.M.
dc.creatorSilva, Pedro L.
dc.date2017-11-14T11:45:39Z
dc.date2017-11-14T11:45:39Z
dc.date2017
dc.date.accessioned2023-09-26T20:14:01Z
dc.date.available2023-09-26T20:14:01Z
dc.identifierMENDONÇA, Lucas de; et al. Mesenchymal stromal cell therapy reduces lung inflammation and vascular remodeling and improves hemodynamics in experimental pulmonary arterial hypertension. Stem Cell Research & Therapy, v.8:220, 15p, 2017.
dc.identifier1757-6512
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/23147
dc.identifier10.1186/s13287-017-0669-0
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8852046
dc.descriptionExperimental research has reported beneficial effects of mesenchymal stromal cell (MSC) therapy in pulmonary arterial hypertension (PAH). However, these studies either were based on prophylactic protocols or assessed basic remodeling features without evaluating possible mechanisms. We analyzed the effects of MSC therapy on lung vascular remodeling and hemodynamics and its possible mechanisms of action in monocrotaline (MCT)-induced PAH.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioMed Central
dc.rightsopen access
dc.subjectHemodinâmica
dc.subjectHipertensão arterial pulmonar
dc.subjectRemodelação vascular do pulmão
dc.subjectCélulas do estroma mesenquimal
dc.subjectFenótipo de macrófagos
dc.subjectPulmonary arterial hypertension
dc.subjectMesenchymal stromal cells
dc.subjectHemodynamics
dc.subjectLung vascular remodeling
dc.subjectMacrophage phenotype
dc.titleMesenchymal stromal cell therapy reduces lung inflammation and vascular remodeling and improves hemodynamics in experimental pulmonary arterial hypertension
dc.typeArticle


Este ítem pertenece a la siguiente institución