Genotypic and Epidemiologic Profiles of Giardia duodenalis in Four Brazilian Biogeographic Regions

dc.creatorCalegar, Deiviane A.
dc.creatorNunes, Beatriz C.
dc.creatorMonteiro, Kerla J. L.
dc.creatorBacelar, Polyanna A. A.
dc.creatorEvangelista, Brenda B. C.
dc.creatorAlmeida, Mayron M.
dc.creatorSilva, Jurecir
dc.creatorSantos, Jéssica P.
dc.creatorBoia, Márcio Neves
dc.creatorJaeger, Lauren H.
dc.creatorCosta, Filipe A. Carvalho
dc.date2022-07-24T14:15:20Z
dc.date2022-07-24T14:15:20Z
dc.date2022
dc.date.accessioned2023-09-26T20:13:39Z
dc.date.available2023-09-26T20:13:39Z
dc.identifierCALEGAR, Deiviane A. et al. Genotypic and Epidemiologic Profiles of Giardia duodenalis in Four Brazilian Biogeographic Regions. Microorganisms, v. 10, n. 940, p. 1 - 14, Apr. 2022.
dc.identifier2076-2607
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/53928
dc.identifier10.3390/microorganisms10050940
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8851891
dc.descriptionHuman infections with gut protozoan parasites are neglected and not targeted by specific control initiatives, leading to a knowledge gap concerning their regional diversity and epidemiology. The present study aims to explore Giardia duodenalis genetic diversity and assess the epidemiologic scenario of subclinical infections in different Brazilian biogeographic regions. Cross-sectional surveys (n = 1334 subjects) were conducted in four municipalities in order to obtain fecal samples and socioenvironmental data. Microscopy of non-diarrheal feces and nucleotide sequencing of a -giardin gene fragment were performed. From a total of 51 samples that could be sequenced, 27 (52.9%) -giardin sequences were characterized as assemblage A and 24 (47.1%) as assemblage B. In the Amazon, assemblage B was the most frequently detected, predominantly BIII, and with two novel sub-assemblages. Assemblage A predominated in the extra-Amazon region, with five novel subassemblages. Prevalence reached 17.8% (64/360) in the Amazon, 8.8% (48/544) in the Atlantic Forest, 7.4% (22/299) in Cerrado and 2.3% (3/131) in the Semiarid. People living in poverty and extreme poverty presented significantly higher positivity rates. In conclusion, subclinical giardiasis is endemic in Brazilian communities in different biogeographic regions, presenting high genetic diversity and a heterogeneous genotypic distribution.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectGiardia duodenalis
dc.subjectDiversidade genética
dc.subjectEpidemiologia
dc.subjectMontagens
dc.subjectRegiões biogeográficas brasileiras
dc.subjectGiardia duodenalis
dc.subjectAssemblages
dc.subjectEpidemiology
dc.subjectGenetic diversity
dc.subjectBrazilian Biogeographic Regions
dc.titleGenotypic and Epidemiologic Profiles of Giardia duodenalis in Four Brazilian Biogeographic Regions
dc.typeArticle


Este ítem pertenece a la siguiente institución