Otro
Behavioral effects of acute exposure to the insecticide fipronil
Registro en:
Pesticide Biochemistry and Physiology. San Diego: Academic Press Inc. Elsevier B.V., v. 99, n. 3, p. 221-225, 2011.
0048-3575
10.1016/j.pestbp.2010.12.007
WOS:000288419800003
WOS000288419800003.pdf
Autor
Galbiati Tercariol, Paula Raquel
Godinho, Antonio Francisco
Resumen
The effects of fipronil (Frontline (R) Top Spot) were investigated in 40 days old rats utilizing open field (OF), hole-board (HB) and elevated plus-maze (EPM) apparatus. Rats (N=15) received topical application of fipronil (70, 140 and 280 mg/kg) in the neck region and behavior was tested 3 h after administration. Animals treated with corn oil (vehicle) were used as controls. In the of test animals treated with fipronil at 140 mg/kg showed increased rearing, whereas animals exposed to 280 mg/kg showed increased freezing, grooming, and rearing. In the HB test fipronil at 280 mg/kg increased head-dip and head-dipping behaviors. In the EPM test the only observed effect was increased number of entries in both open and closed EPM arms in animals treated with 280 mg/kg. In conclusion, dermal exposure to fipronil causes effects related to emotionality, fear, and exploratory activity; results add strength to the growing concern that pirazole insecticides can be neurotoxic to humans. Published by Elsevier B.V.