Is the thymus a target organ in infectious diseases?

dc.creatorSavino, Wilson
dc.creatorMoraes, Maria do Carmo Leite de
dc.creatorBarbosa, Suse Dayse Silva
dc.creatorFonseca, Eliene Carvalho da
dc.creatorAlmeida, Vinicius Cotta de
dc.creatorHontebeyrie-Joscowicz, Mireille
dc.date2019-06-18T16:45:08Z
dc.date2019-06-18T16:45:08Z
dc.date1992
dc.date.accessioned2023-09-26T20:13:07Z
dc.date.available2023-09-26T20:13:07Z
dc.identifierSAVINO, Wilson et al. Is the thymus a target organ in infetious diseases. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, Suppl. V, p. 73-78, 1992.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33552
dc.identifier10.1590/s0074-02761992000900010
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8851669
dc.descriptionThe thymus is a central lymphoid organ, in wich T cell precursors differentiale and generate most of the so-called T cell reprtoire. Along with a variety of acute infectious diseases, we and others determined important changes in both microenvironmental and lymphoid compartments of the organ. For example, one major and common feature observed in acute viral, bacterial and parasitic diseases, is a depletion of cortical thymocytes, mostly those bearing the CD4-CD8 double positive phenotype. This occurs simmultaneously to the relative enrichment in medullary CD4 or CD8 single positive cells, expressing high densities of the CD3 complex. Additionally we noticed a variety of changes in the thymic microenvironment (and particularly is epithelial component), comprising abnormal location of thymic epithelial cell subsets as well has a denser Ia-bearing cellular network. Moreover, the extracellular matrix network was altered with an intralobular increase of basement membrane proteins that positively correlated with the degree of thymocyte death. Lastly, anti-thymic cell antibodies were detected in both human and animal models of infectious diseases, and in some of them a phenomenon of molecular mimicry could be evidenced. Taken together, the data receiwed herein clearly show that the thymus should be regarded as a target in infectious diseases.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectTimo
dc.subjectDoenças infecciosas
dc.subjectTimócitos
dc.subjectEsquistossomose
dc.subjectAIDS
dc.subjectMicroambiente tímico
dc.subjectDoença de Chagas
dc.subjectThymus
dc.subjectThymic microenvironment
dc.subjectThymocites
dc.subjectInfectious diseases
dc.subjectChagas disease
dc.subjectSchistosomiasis
dc.subjectAIDS
dc.titleIs the thymus a target organ in infectious diseases?
dc.typeArticle


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