Mesenchymal Stem Cells and Atopic Dermatitis: A Review

dc.creatorDaltro, Sérgio Ricardo Teixeira
dc.creatorMeira, Cássio Santana
dc.creatorSantos, Ivanilson Pimenta
dc.creatorSantos, Ricardo Ribeiro dos
dc.creatorSoares, Milena Botelho Pereira
dc.date2020-09-18T12:05:13Z
dc.date2020-09-18T12:05:13Z
dc.date2020
dc.date.accessioned2023-09-26T20:12:57Z
dc.date.available2023-09-26T20:12:57Z
dc.identifierDALTRO, Sérgio Ricardo Teixeira et al. Mesenchymal Stem Cells and Atopic Dermatitis: A Review. Frontiers in Cell and Developmental Biology, v. 8, Article 326, p. 1-10, May 2020.
dc.identifier2296-634X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/43444
dc.identifier10.3389/fcell.2020.00326
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8851595
dc.descriptionBrazilian Research Council (CNPq)/MS Grant No. 443909/2018-0.
dc.descriptionMesenchymal stem/stromal cells (MSCs) are stromal-derived non-hematopoietic progenitor cells that reside in and can be expanded from various tissues sources of adult and neonatal origin, such as the bone marrow, umbilical cord, umbilical cord blood, adipose tissue, amniotic fluid, placenta, dental pulp and skin. The discovery of the immunosuppressing action of MSCs on T cells has opened new perspectives for their use as a therapeutic agent for immune-mediated disorders, including allergies. Atopic dermatitis (AD), a chronic and relapsing skin disorder that affects up to 20% of children and up to 3% of adults worldwide, is characterized by pruritic eczematous lesions, impaired cutaneous barrier function, Th2 type immune hyperactivation and, frequently, elevation of serum immunoglobulin E levels. Although, in the dermatology field, the application of MSCs as a therapeutic agent was initiated using the concept of cell replacement for skin defects and wound healing, accumulating evidence have shown that MSC-mediated immunomodulation can be applicable to the treatment of inflammatory/allergic skin disorders. Here we reviewed the pre-clinical and clinical studies and possible biological mechanisms of MSCs as a therapeutic tool for the treatment of atopic dermatitis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectCélulas-tronco mesenquimais / estromais,
dc.subjectDermatite atópica
dc.subjectEczema atópico
dc.subjectImunomodulação
dc.subjectInflamação
dc.subjectDoenças de pele
dc.subjectMesenchymal stem/stromal cells
dc.subjectAtopic dermatitis
dc.subjectAtopic eczema
dc.subjectImmunomodulation
dc.subjectInflammatory skin diseases
dc.titleMesenchymal Stem Cells and Atopic Dermatitis: A Review
dc.typeArticle


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