Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion

dc.creatorSpencer, Lisa A.
dc.creatorMelo, Rossana C. N.
dc.creatorPerez, Sandra A. C.
dc.creatorBafford, Staci P.
dc.creatorDvorak, Ann M.
dc.creatorWeller, Peter F.
dc.date2020-02-04T14:56:42Z
dc.date2020-02-04T14:56:42Z
dc.date2006
dc.date.accessioned2023-09-26T20:12:54Z
dc.date.available2023-09-26T20:12:54Z
dc.identifierSPENCER, Lisa A. et al. Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Proceedings of the National Academy of Sciences (PNAS), v. 103, n. 9, p. 3333-3338, Feb. 2006.
dc.identifier0027-8424
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/39713
dc.identifier10.1073/pnas.0508946103
dc.identifier1091-6490
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8851574
dc.descriptionAlthough leukocytes of the innate immune system, including eosinophils, contain within their granules preformed stores of cytokines available for selective and rapid release, little is known about the mechanisms governing the mobilization and secretion of these cytokines. Here we show that a cytokine receptor, the IL-4 receptor alpha chain, mediates eotaxin-stimulated mobilization of preformed IL-4 from eosinophil granules into secretory vesicles. Eosinophils contain substantial intracellular quantities of several granule- and vesicle-associated cytokine receptors, including IL-4, IL-6, and IL-13 receptors as well as CCR3. Both IL-4 and IL-4 receptor alpha chain colocalized in eosinophil granules; and after eotaxin-stimulation, IL-4 receptor alpha chain, bearing bound IL-4, was mobilized into secretory vesicles. These findings indicate that intracellular cytokine receptors within secretory vesicles transport their cognate cytokines requisite for the secretion of cytokines preformed in innate immune leukocytes.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNational Academy of Sciences
dc.rightsopen access
dc.subjectReceptor intracelular de citocinas
dc.subjectTransporte vesicular
dc.subjectTráfico intracelular de citocinas
dc.subjectDegranulação fragmentada
dc.subjectIntracellular cytokine receptor
dc.subjectIntracellular cytokine trafficking
dc.subjectPiecemeal degranulation
dc.subjectVesicular transport
dc.titleCytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion
dc.typeArticle


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