mCSM-AB: a web server for predicting antibody-antigen affinity changes upon mutation with graph-based signatures

dc.creatorPires, Douglas Eduardo Valente
dc.creatorAscher, David Benjamin
dc.date2017-08-18T18:33:28Z
dc.date2017-08-18T18:33:28Z
dc.date2016
dc.date.accessioned2023-09-26T20:12:35Z
dc.date.available2023-09-26T20:12:35Z
dc.identifierPIRES, Douglas Eduardo Valente; ASCHER, David B. mCSM-AB: a web server for predicting antibody-antigen affinity changes upon mutation with graph-based signatures. Nucleic Acids Res., v. 44, n. W1, W469-73, 2016.
dc.identifier0305-1048
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/20686
dc.identifier10.1093/nar/gkw458
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8851435
dc.descriptionComputational methods have traditionally struggled to predict the effect of mutations in antibody-antigen complexes on binding affinity. This has limited their usefulness during antibody engineering and development, and their ability to predict biologically relevant escape mutations. Here we present mCSM-AB, a user-friendly web server for accurately predicting antibody-antigen affinity changes upon mutation which relies on graph-based signatures. We show that mCSM-AB performs better than comparable methods that have been previously used for antibody engineering. mCSM-AB web server is available at http://structure.bioc.cam.ac.uk/mcsm_ab.
dc.description2028-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsrestricted access
dc.subjectanticorpos
dc.subjectAntibodies/chemistry
dc.subjectAntigens/immunology
dc.subjectProtein Engineering
dc.titlemCSM-AB: a web server for predicting antibody-antigen affinity changes upon mutation with graph-based signatures
dc.typeArticle


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