Genome-wide signatures of complex introgression and adaptive evolution in the big cats

dc.creatorFigueiró, Henrique Vieira
dc.creatorLi, Gang
dc.creatorTrindade, Fernanda J.
dc.creatorGeraldo, Juliana Assis
dc.creatorPais, Fabiano Sviatopolk Mirsky
dc.creatorFernandes, Gabriel da Rocha
dc.creatorSantos, Sarah H. D.
dc.creatorHughes, Graham M.
dc.creatorKomissarov, Aleksey
dc.creatorAntunes, Agostinho
dc.creatorTrinca, Cristine S.
dc.creatorRodrigues, Maíra R.
dc.creatorLinderoth, Tyler
dc.creatorBi, Ke
dc.creatorSilveira, Leandro
dc.creatorAzevedo, Fernando C. C.
dc.creatorKantek, Daniel
dc.creatorRamalho, Emiliano
dc.creatorBrassaloti, Ricardo A.
dc.creatorVillela, Priscilla M. S.
dc.creatorNunes, Adauto L. V.
dc.creatorTeixeira, Rodrigo H. F.
dc.creatorMorato, Ronaldo G.
dc.creatorLoska, Damian
dc.creatorSaragüeta, Patricia
dc.creatorGabaldón, Toni
dc.creatorTeeling, Emma C.
dc.creatorO’Brien, Stephen J.
dc.creatorNielsen, Rasmus
dc.creatorCoutinho, Luiz L.
dc.creatorOliveira, Guilherme Corrêa de
dc.creatorMurphy, William J.
dc.creatorEizirik, Eduardo
dc.date2018-04-18T12:48:24Z
dc.date2018-04-18T12:48:24Z
dc.date2017
dc.date.accessioned2023-09-26T20:12:15Z
dc.date.available2023-09-26T20:12:15Z
dc.identifierFIGUEIRÓ, Henrique Vieira et al. Genome-wide signatures of complex introgression and adaptive evolution in the big cats. Sci Adv., v. 3, n. 7, e1700299, 2017.
dc.identifier2375-2548
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25924
dc.identifier10.1126/sciadv.1700299
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8851280
dc.descriptionThe great cats of the genus Panthera comprise a recent radiation whose evolutionary history is poorly understood. Their rapid diversification poses challenges to resolving their phylogeny while offering opportunities to investigate the historical dynamics of adaptive divergence. We report the sequence, de novo assembly, and annotation of the jaguar (Panthera onca) genome, a novel genome sequence for the leopard (Panthera pardus), and comparative analyses encompassing all living Panthera species. Demographic reconstructions indicated that all of these species have experienced variable episodes of population decline during the Pleistocene, ultimately leading to small effective sizes in present-day genomes. We observed pervasive genealogical discordance across Panthera genomes, caused by both incomplete lineage sorting and complex patterns of historical interspecific hybridization. We identified multiple signatures of species-specific positive selection, affecting genes involved in craniofacial and limb development, protein metabolism, hypoxia, reproduction, pigmentation, and sensory perception. There was remarkable concordance in pathways enriched in genomic segments implicated in interspecies introgression and in positive selection, suggesting that these processes were connected. We tested this hypothesis by developing exome capture probes targeting ~19,000 Panthera genes and applying them to 30 wild-caught jaguars. We found at least two genes (DOCK3 and COL4A5, both related to optic nerve development) bearing significant signatures of interspecies introgression and within-species positive selection. These findings indicate that post-speciation admixture has contributed genetic material that facilitated the adaptive evolution of big cat lineages.
dc.description2022-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Association for the Advancement of Science
dc.rightsrestricted access
dc.subjectgatos
dc.subjectcats
dc.titleGenome-wide signatures of complex introgression and adaptive evolution in the big cats
dc.typeArticle


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