Infiltrating CD57+ inflammatory cells in head and neck squamous cell carcinoma: clinicopathological analysis and prognostic significance

dc.creatorFraga, Carlos Alberto de Carvalho
dc.creatorOliveira, Marcos Vinícius Macedo de
dc.creatorDomingos, Patrícia Luciana Batista
dc.creatorBotelho, Ana Cristina de Carvalho
dc.creatorGuimarães, Andre Luiz Sena
dc.creatorCarvalho, Andréa Teixeira de
dc.creatorOliveira, Rodrigo Corrêa de
dc.creatorPaula, Alfredo Maurício Batista de
dc.date2014-03-12T17:23:50Z
dc.date2014-03-12T17:23:50Z
dc.date2012
dc.date.accessioned2023-09-26T20:12:13Z
dc.date.available2023-09-26T20:12:13Z
dc.identifierCARVALHO FRAGA, Carlos Alberto de et al. Infiltrating CD57+ inflammatory cells in head and neck squamous cell carcinoma: clinicopathological analysis and prognostic significance. Applied Immunohistochemistry & Molecular Morphology. 2012, vol.20, n.3, pp. 285-290.
dc.identifier1533-4058
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7398
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8851263
dc.descriptionFundação de Amparo a Pesquisa no Estado de Minas Gerais (FAPEMIG) and Coordenação de Aperfeiçoamento de Pessoal de Nıvel Superior (CAPES)
dc.descriptionThis study investigated the immunodetection of CD57 + inflammatory cells in patients with head and neck squamous cell carcinoma (HNSCC) and its association with clinicopathological parameters and overall survival. Data collected from the morphological analysis and immunohisto-chemical reaction testing of archived HNSCC specimens (n=70) were statistically analyzed by bivariate and multivariate statistical testing at a significance level of P < 0.05. The results indicate that CD57 + inflammatory cells predominate within the peritumoral stroma of HNSCC lesions and the existence of two significant relationships: between high CD57 + cell density and the development of a tumor of a large size [odds ratio (OR)=5.610, 95% confidence interval (CI)=1.516–20.763) and between high CD57 + cell density and the development of locoregional metastatic disease (OR=3.401, 95% CI= 1.162–9.951). A significant difference in the rate of survival was detected only in HNSCC patients that presented large size tumors (OR=4.747, 95% CI=1.281–17.594). Together, these results suggest that although high CD57 + inflammatory cell density is associated with HNSCC lesions of greater clinical severity, the variable of cell density is not an independent predictor of HNSCC patient survival. Our findings also suggest that the relatively aggressive infiltration of CD57 + inflamma-tory cells in the peritumoral stroma of head and neck carcinomas may contribute to an ineffective locoregional antitumoral response.
dc.formatapplication/pdf
dc.languagepor
dc.publisherLippincott Williams & Wilkins
dc.rightsrestricted access
dc.subjectsquamous cell carcinoma
dc.subjecthead and neck
dc.subjectCD57 + inflammatory cells
dc.subjectclinicopathological factors
dc.subjectprognosis
dc.titleInfiltrating CD57+ inflammatory cells in head and neck squamous cell carcinoma: clinicopathological analysis and prognostic significance
dc.typeArticle


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