Visceral Leishmaniasis in Hospitalized HIV-Infected Patients in Pernambuco, Brazil

dc.creatorGuedes, Diego Lins
dc.creatorMedeiros, Zulma
dc.creatorSilva, Elis Dionísio da
dc.creatorVasconcelos, Audrey Violeta Martins de
dc.creatorSilva, Mariana Santana da
dc.creatorSilva, Maria Almerice Lopes da
dc.creatorAraújo, Paulo Sérgio Ramos de
dc.creatorMiranda-Filho, Demócrito de Barros
dc.date2019-11-04T15:11:49Z
dc.date2019-11-04T15:11:49Z
dc.date2018
dc.date.accessioned2023-09-26T20:12:04Z
dc.date.available2023-09-26T20:12:04Z
dc.identifierGUEDES, Diego Lins et al. Visceral Leishmaniasis in Hospitalized HIV-Infected Patients in Pernambuco, Brazil. The American Journal of Tropical Medicine and Hygiene, v. 99, n. 6, p. 1541-1546, 2018.
dc.identifier0002-9637
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36844
dc.identifier10.4269/ajtmh.17-0787
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8851187
dc.descriptionCommon in four continents, visceral leishmaniasis (VL) is an important but neglected disease. Human immunodeficiency virus (HIV) infection increases the risk of developing VL in people from leishmaniasis-endemic areas, with worse prognosis when there is coinfection. We conducted a cross-sectional study to determine the prevalence of HIV/VL coinfection in patients admitted in three referral hospitals for HIV/acquired immunodeficiency syndrome (AIDS) in Pernambuco, Brazil, and to compare epidemiological, clinical, and laboratory characteristics among HIV/VL coinfected and HIV mono-infected individuals. The sample consisted of HIV patients aged 18 years or more, in a period of data collection of 6 months. We performed four Leishmania tests-polymerase chain reaction (PCR), direct agglutination test, rK39, and latex agglutination test-and individuals with at least one positive test were considered coinfected. The HIV/VL coinfection prevalence we found was 16.9%. We observed large variation in prevalence according to the Leishmania test used, with low coincidence of positive tests. The most frequent symptoms found were weight loss (75.6%), fever (67.6%), and cough (55.3%). When we compared HIV/VL coinfected and HIV mono-infected groups we did not observe statistically significant differences. Low educational level (P = 0.004) and pallor (P = 0.009) were more frequent in the coinfected group. Serum albumin level was higher in coinfected individuals (P = 0.009). It is important to follow-up these individuals to understand the dynamics of VL in people living with HIV. New tests are necessary, ideally differentiating active from latent infection. Testing for VL in people with HIV is important and should be considered as part of the initial investigation in these individuals.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectVisceral Leishmaniasis
dc.subjectHIV-Infected Patients
dc.subjectBrazil
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectTestes de Aglutinação
dc.subjectBrasil / epidemiologia
dc.subjectCoinfecção
dc.subjectEstudos Transversais
dc.subjectFeminino
dc.subjectHIV / genética
dc.subjectHIV / imunologia
dc.subjectHIV/ / isolamento & purificação
dc.subjectInfecções por HIV / epidemiologia
dc.subjectInfecções por HIV / parasitologia
dc.subjectInfecções por HIV / fisiopatologia
dc.subjectInfecções por HIV / virologia
dc.subjectHospitalização
dc.subjectHumanos
dc.subjectLeishmania / genética
dc.subjectLeishmania / imunologia
dc.subjectLeishmania / isolamento & purificação
dc.subjectLeishmaniose Visceral / epidemiologia
dc.subjectLeishmaniose Visceral / parasitologia
dc.subjectLeishmaniose Visceral / fisiopatologia
dc.subjectLeishmaniose Visceral / virologia
dc.subjectMasculino
dc.subjectPessoa de Meia-Idade
dc.subjectReação em Cadeia da Polimerase
dc.subjectEpidemiologia
dc.titleVisceral Leishmaniasis in Hospitalized HIV-Infected Patients in Pernambuco, Brazil
dc.typeArticle


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