Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging

dc.creatorCosta, Maria Fernanda Lima
dc.creatorMacinko, James
dc.creatorMambrini, Juliana Vaz de Melo
dc.creatorPeixoto, Sérgio William Viana
dc.creatorPereira, Alexandre da Costa
dc.creatorTarazona, Eduardo Martins
dc.creatorRibeiro, Antonio Luiz Pinho
dc.date2017-07-12T17:54:37Z
dc.date2017-07-12T17:54:37Z
dc.date2016
dc.date.accessioned2023-09-26T20:11:50Z
dc.date.available2023-09-26T20:11:50Z
dc.identifierCOSTA, Maria Fernanda Lima et al. Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging. PLOS Neglected Tropical Diseases, v. 10, n. 5. Art. e0004724, 2016.
dc.identifier1935-2727
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/20059
dc.identifier10.1371/journal.pntd.0004724
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8851088
dc.descriptionBackground: The influence of genetic ancestry on Trypanosoma cruzi infection and Chagas disease outcomes is unknown. Methodology/Principal Findings: We used 370,539 Single Nucleotide Polymorphisms (SNPs) to examine the association between individual proportions of African, European and Native American genomic ancestry with T. cruzi infection and related outcomes in 1,341 participants (aged ≥ 60 years) of the Bambui (Brazil) population-based cohort study of aging. Potential confounding variables included sociodemographic characteristics and an array of health measures. The prevalence of T. cruzi infection was 37.5% and 56.3% of those infected had a major ECG abnormality. Baseline T. cruzi infection was correlated with higher levels of African and Native American ancestry, which in turn were strongly associated with poor socioeconomic circumstances. Cardiomyopathy in infected persons was not significantly associated with African or Native American ancestry levels. Infected persons with a major ECG abnormality were at increased risk of 15-year mortality relative to their counterparts with no such abnormalities (adjusted hazard ratio = 1.80; 95% 1.41, 2.32). African and Native American ancestry levels had no significant effect modifying this association. Conclusions/Significance: Our findings indicate that African and Native American ancestry have no influence on the presence of major ECG abnormalities and had no influence on the ability of an ECG abnormality to predict mortality in older people infected with T. cruzi. In contrast, our results revealed a strong and independent association between prevalent T. cruzi infection and higher levels of African and Native American ancestry. Whether this association is a consequence of genetic background or differential exposure to infection remains to be determined.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjecteletrocardiograma
dc.subjectTrypanosoma cruzi
dc.subjectElectrocardiography
dc.subjectTrypanosoma cruzi
dc.subjectNative Americans
dc.subjectSocioeconomic aspects of health
dc.subjectCholesterol
dc.subjectCardiomyopathies
dc.subjectCohort studies
dc.subjectCoronary heart disease
dc.titleGenomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging
dc.typeArticle


Este ítem pertenece a la siguiente institución