A comparison of sonographic assessments and clinical questionnaire in the diagnosis of HIV-associated lipodystrophy

dc.creatorSignorini, Dario José Hart Pontes
dc.creatorOliveira Netto, Ana Maria Schmidt de
dc.creatorMonteiro, Michelle Carreira Miranda
dc.creatorGabbay, Sergio
dc.creatorAndrade, Marion de Fátima Castro de
dc.creatorBastos, Francisco Inácio Pinkusfeld Monteiro
dc.creatorCodeço, Cláudia Torres
dc.date2012-05-02T02:53:30Z
dc.date2012-05-02T02:53:30Z
dc.date2011
dc.date.accessioned2023-09-26T20:11:07Z
dc.date.available2023-09-26T20:11:07Z
dc.identifierSIGNORINI, Dario José Hart Pontes et al. A Comparison of sonographic assessments and clinical questionnaire in the diagnosis of HIV-associated lipodystrophy. Journal of the International Association of Physicians in AIDS Care, Chicago, v. 10, n. 6, p. 351-356, Nov./Dec. 2011.
dc.identifier1545-1097
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/3869
dc.identifier10.1177/1545109711399660
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850734
dc.descriptionThe study evaluated the use of sonographic measurements as an alternative to assessments based on clinical or other imaging techniques for the diagnosis of body-fat abnormalities. The study enrolled 179 HIV-infected patients, 81 (45.3%) of them diagnosed as lipodystrophy (LD)-positive based on a clinical standard questionnaire. Association between clinical LD and sonographic measurements of face, right upper limb, subcutaneous abdomen, and visceral compartments was evaluated by multiple logistic regression. The predicted probability of the logistic model was 0.64, corresponding to a maximum sensitivity of 69.1% (58%-79%), a specificity of 94.9% (88%-98%), and to positive and negative predictive values of 92% (82%-97%) and 79% (70%-86%), respectively. Kappa measure of concordance was 65% (54%-77%). Low sensitivity poses a problem for the use of sonography to detect LD in the clinical routine as a single exam, speaking in favor of the combined use of clinical and sonographic measurements over time.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSAGE Publications
dc.rightsopen access
dc.subjectHIV-associated lipodystrophy syndrome
dc.subjectAnti-HIV agents
dc.subjectROC curve
dc.subjectUltrasonography
dc.subjectLogistic models
dc.subjectSensitivity and specificity
dc.subjectSíndrome de Lipodistrofia Associada ao HIV/diagnóstico
dc.subjectFármacos Anti-HIV
dc.subjectCurva ROC
dc.subjectQuestionário
dc.subjectModelos Logísticos
dc.subjectSensibilidade e Especificidade
dc.titleA comparison of sonographic assessments and clinical questionnaire in the diagnosis of HIV-associated lipodystrophy
dc.typeArticle


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