Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection

dc.creatorLima, Clara Mônica
dc.creatorSantos, Silvane Maria Braga
dc.creatorDourado, Adriana
dc.creatorCarvalho, Natália Barbosa
dc.creatorBittencourt, Valéria
dc.creatorLessa, Marcus Miranda
dc.creatorSiqueira, Isadora Cristina de
dc.creatorCarvalho Filho, Edgar Marcelino
dc.date2017-02-08T16:51:04Z
dc.date2017-02-08T16:51:04Z
dc.date2016
dc.date.accessioned2023-09-26T20:11:03Z
dc.date.available2023-09-26T20:11:03Z
dc.identifierLIMA, C. M. et al. Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection. Journal of Immunology Research, article ID 8402059, 2016.
dc.identifier2314-8861
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/17748
dc.identifier10.1155/2016/8402059
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850703
dc.descriptionThe Sjögren syndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis of Sjögren syndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with HTLV-1 in patients without myelopathy. Subjects were recruited in the HTLV-1 Clinic, from 2009 to 2011. The proviral load and cytokine levels (IFN-γ, TNF-α, IL-5, and IL-10) were obtained from a database containing the values presented by the subjects at admission in the clinic. Of the 272 participants, 59 (21.7%) had sicca syndrome and in all of them anti-Sjögren syndrome related antigen A (SSA) and antigen B (SSB) were negatives. The production of TNF-α and IFN-γ was higher in the group with sicca syndrome (P < 0.05) than in HTLV-1 infected subjects without sicca syndrome. Our data indicates that patients with sicca syndrome associated with HTLV-1 do not have Sjögren syndrome. However the increased production of TNF-α and IFN-γ in this group of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.rightsopen access
dc.subjectInfecções por HTLV-I
dc.subjectVírus linfotrópico T humano 1
dc.subjectRegulação da expressão genética
dc.subjectHumanos
dc.subjectInterleucina-10
dc.subjectProviruses
dc.subjectSíndrome de Sjogren
dc.subjectNecrose Tumoral
dc.subjectCarga Viral
dc.subjectHTLV-I Infections
dc.subjectT-lymphotropic virus 1 Human
dc.subjectGene Expression Regulation
dc.subjectHuman
dc.subjectInterleukin-10
dc.subjectProviruses
dc.subjectSjogren's Syndrome
dc.subjectTumor Necrosis
dc.subjectViral Load
dc.titleAssociation of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection
dc.typeArticle


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