| dc.creator | Silva, Fernanda de Oliveira | |
| dc.creator | Teixeira, Eliane de Morais | |
| dc.creator | Rabello, Ana Lucia Teles | |
| dc.date | 2022-07-04T17:31:01Z | |
| dc.date | 2022-07-04T17:31:01Z | |
| dc.date | 2008 | |
| dc.date.accessioned | 2023-09-26T20:10:53Z | |
| dc.date.available | 2023-09-26T20:10:53Z | |
| dc.identifier | SILVA, Fernanda de Oliveira; TEIXEIRA, Eliane de Morais; RABELLO, Ana Lucia Teles. Antileishmanial activity of azithromycin against Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, and Leishmania (Leishmania) chagasi. Am J Trop Med Hyg., v. 78, n. 5, p. 745-749, 2008. | |
| dc.identifier | 0002-9637 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/53628 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8850632 | |
| dc.description | CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO | |
| dc.description | Azithromycin, an azalide antibiotic, is highly concentrated within different phagocytic cells, especially macrophages. The potential antileishmanial activity of azithromycin against three species of Leishmania from the New World was assessed using in vitro models. Azithromycin decreased viability of promastigote cultures of Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, and Leishmania (Leishmania) chagasi as determined by the colorimetric Alamar blue assay. In amastigote intracellular cultures, a significant decrease in infected macrophages counts was observed for all three species with IC50 of 20.83 (27 mu mol/L), 2.18 (2.7 mu mol/L), and 6.12 (7.8 mu mol/L) mu g/mL, respectively. Azithromycin showed in vitro activity against L. (L.) amazonensis, L. (V.) braziliensis, and L. (L.) chagasi and may offer an alternative to current leishmaniasis treatment | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | American Society of Tropical Medicine and Hygiene | |
| dc.rights | restricted access | |
| dc.title | Antileishmanial activity of azithromycin against Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, and Leishmania (Leishmania) chagasi | |
| dc.type | Article | |
