Purinergic receptors and neglected tropical diseases: why ignore purinergic signaling in the search for new molecular targets?

dc.creatorPacheco, P. A. F.
dc.creatorDantas, L. P.
dc.creatorFerreira, L. G. B.
dc.creatorFaria, Robson Xavier
dc.date2018-10-05T18:46:50Z
dc.date2018-10-05T18:46:50Z
dc.date2018
dc.date.accessioned2023-09-26T20:10:50Z
dc.date.available2023-09-26T20:10:50Z
dc.identifierPACHECO, P. A. F. et al. Purinergic receptors and neglected tropical diseases: why ignore purinergic signaling in the search for new molecular targets?. Journal of Bioenergetics and Biomembranes, v.50, p.307–313, 2018.
dc.identifier0145-479X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29405
dc.identifier10.1007/s10863-018-9761-0
dc.identifier573-6881
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850607
dc.descriptionPurinergic receptors are widespread in the human organism and are involved in several physiological functions like neurotransmission, nociception, platelet aggregation, etc. In the immune system, they may regulate the expression and release of pro-inflammatory factors as well as the activation and death of several cell types. It is already described the participation of some purinergic receptors in the inflammation and pathological processes, such as a few neglected tropical diseases (NTDs) which affect more than 1 billion people in the world. Although the high social influence those diseases represent endemic countries, most of them do not have an efficient, safe or affordable drug treatment. In that way, this review aims to discuss the current literature involving purinergic receptor and immune response to NTDs pathogens, which may contribute in the search for new therapeutic possibilities.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Verlag (Germany)
dc.rightsrestricted access
dc.subjectReceptores purinérgicos
dc.subjectDoenças negligenciadas
dc.subjectTerapia
dc.subjectATP
dc.subjectPurinergic receptors
dc.subjectATP
dc.subjectNeglected diseases
dc.subjectTherapy
dc.titlePurinergic receptors and neglected tropical diseases: why ignore purinergic signaling in the search for new molecular targets?
dc.typeArticle


Este ítem pertenece a la siguiente institución