On the presence of hepatic stellate cells in portal spaces

dc.creatorFonseca, Yannick de Oliveira
dc.creatorLima, Camila Bião
dc.creatorSantos, Elisângela Trindade
dc.creatorAndrade, Zilton de Araújo
dc.date2011-08-30T13:45:19Z
dc.date2011-08-30T13:45:19Z
dc.date2011
dc.date.accessioned2023-09-26T20:10:33Z
dc.date.available2023-09-26T20:10:33Z
dc.identifierFONSECA, Y. de O. et al. On the presence of hepatic stellate cells in portal spaces. Memórias do Instituto Oswaldo Cruz, v. 100, n. 3, p. 289-291, 2005.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/2818
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850475
dc.descriptionPrevious studies in mice with hypervitaminosis A have demonstrated that fat-storing cells (hepatic stellate cells- HSCs) participate in schistosomal granuloma fibrogenesis. The origin of such cells in portal areas, away from the Disse spaces, was herein investigated. HSCs were identified in frozen sections of the liver by means of Sudan III staining. They appeared as red-stained cells disposed along the sinusoids of normal mice, but were never found within portal spaces. However, in the chronically inflamed portal spaces of Capillaria hepatica-infected mice, Sudan III-positive cells were frequently present among leukocytes and fibroblast-like cells. Thus, there are no resident HSCs in portal spaces, but their presence there in chronic inflammatory processes indicates that they are able to migrate from peri-sinusoidal areas in order to reach the portal areas
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectEspaço Extracelular
dc.subjectHepatócitos
dc.subjectCirrose Hepática
dc.subjectSistema Porta
dc.subjectHistocitoquímica
dc.subjectAnimais
dc.subjectCamundongos
dc.subjectRatos Wistar
dc.subjectHepatic stelate cells
dc.subjectPortal fibrosis
dc.subjectPortal myofibroblasts
dc.subjectEspaço Extracelular
dc.subjectHepatócitos
dc.subjectCirrose Hepática
dc.subjectSistema Porta
dc.titleOn the presence of hepatic stellate cells in portal spaces
dc.typeArticle


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