The chemokines secretion and the oxidative stress are targets of low-level laser therapy in allergic lung inflammation

dc.creatorCarvalho, Jorge Luis Costa
dc.creatorBrito, Auriléia Aparecida de
dc.creatorOliveira, Ana Paula Ligeiro de
dc.creatorFaria Neto, Hugo Caire de Castro
dc.creatorPereira, Thiago Martini
dc.creatorCarvalho, Regiane Albertini de
dc.creatorAnatriello, Elen
dc.creatorAimbire, Flávio
dc.date2017-03-23T12:17:27Z
dc.date2017-03-23T12:17:27Z
dc.date2016
dc.date.accessioned2023-09-26T20:10:28Z
dc.date.available2023-09-26T20:10:28Z
dc.identifierCARVALHO, Jorge Luis Costa; et al. The chemokines secretion and the oxidative stress are targets of low-level laser therapy in allergic lung inflammation. J. Biophotonics, v.9, n.11–12, p.1208–1221, Sept. 2016.
dc.identifier1864-063X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18127
dc.identifier10.1002/jbio.201600061
dc.identifier1864-0648
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850430
dc.descriptionRecent studies show that low-level laser therapy (LLLT) has an important anti-inflammatory action in acute lung inflammation. The present work explored if laser therapy is able to antagonize eosinophils and allergic inflammation induced by oxidative stress in Balb/c mice. Forty-eight hours after challenge, the leukocyte counting, ROS and nitrite/nitrate level, RANTES, CCL3, CCL8 as well as eotaxins were measured in the bronchoalveolar lavage fluid (BALF) of laser-treated mice or not. Into the lung, some chemokines receptors, the iNOS activity and mRNA expression, and the activities of superoxide dismutase (SOD), catalase, gluthatione, NADPH oxidase activities and thiobarbituric acid reactive species (T-Bars) were measured. Laser-treated allergic mice presented reduction of both the ICAM-1 and eosinophil in the lungs. RANTES, CCL8, CCL3 and eotaxins were reduced in BALF of laser-treated allergic mice. In allergic mice lung LLLT decreased the CCR1 and CCR3 and restored the oxidative stress balance as well. Laser decreased the lipidic peroxidation in allergic mice lung as much as increased SOD, GPx and GR. It shows that LLLT on allergic lung inflammation involves leukocyte-attractant chemokines and endogenous antioxidant. Based on results, LLLT may ultimately become a non- invasive option in allergic lung disease treatment. The top figure illustrates the laser decreasing the eosinophils migration into BALF and the bottom figure shows the laser upregulating the expression of heme-oxygenase (anti-oxidant enzyme) in lung tissue anti-oxidant.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley-VCH Verlag
dc.rightsrestricted access
dc.subjectAsma
dc.subjectTerapia a laser de baixo nível
dc.subjectEosinófilos
dc.subjectQuimiocinas
dc.subjectEstresse Oxidativo
dc.subjectFotobiomodulação
dc.subjectasthma
dc.subjecteosinophils
dc.subjectchemokines
dc.subjectoxidative stress
dc.subjectphotobiomodulation
dc.subjectlow-level laser therapy
dc.titleThe chemokines secretion and the oxidative stress are targets of low-level laser therapy in allergic lung inflammation
dc.typeArticle


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