Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions

dc.creatorLepelletier, Yves
dc.creatorSmaniotto, Salete
dc.creatorHadj-Slimane, Réda
dc.creatorVilla-Verde, Déa Maria Serra
dc.creatorNogueira, Ana Cristina
dc.creatorDardenne, Mireille
dc.creatorHerminie, Olivier
dc.creatorSavino, Wilson
dc.date2019-07-04T13:42:19Z
dc.date2019-07-04T13:42:19Z
dc.date2007
dc.date.accessioned2023-09-26T20:10:17Z
dc.date.available2023-09-26T20:10:17Z
dc.identifierLEPELLETIER, Yves et al. Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions. PNAS, v. 104, n. 13, p. 5545-5550, Mar. 2007.
dc.identifier0027-8424
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33836
dc.identifier10.1073/pnas.0700705104
dc.identifier1091-6490
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850336
dc.descriptionIt is largely established that molecules first discovered in the nervous system are also found in the immune system. Neuropilin-1 (NP-1) was initially identified to mediate semaphorin-induced chemorepulsion during brain development and is also involved in peripheral T cell/dendritic cell interactions. Herein, we studied NP-1 during T cell development in the human thymus. NP-1 is expressed in both cortex and medulla of thymic lobules, being found in distinct CD4/CD8-defined thymocyte subsets. NP-1 is also found in thymic epithelial cells (TEC) in situ and in vitro, and is recruited at the site of TEC–thymocyte contact. Moreover, NP-1 was rapidly up-regulated during thymocyte stimulation by T cell receptor (TCR) and IL-7 or after adhesion to TEC. Semaphorin-3A (Sema-3A), a natural ligand of NP-1, is also present in human thymus, both in TEC and thymocytes, being up-regulated in thymocytes after TCR engagement. Functionally, Sema-3A decreases the adhesion capacity of NP-1 thymocytes and induces their migration by a repulsive effect. In conclusion, we show here that NP-1/Sema-3A-mediated interactions participate in the control of human thymocyte development.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNational Academy of Sciences
dc.rightsopen access
dc.subjectMatriz Extracelular
dc.subjectAdesão e migração de timócitos
dc.subjectIntegrinas
dc.subjectExtracellular matrix
dc.subjectIntegrins
dc.subjectThymocyte adhesion and migration
dc.subjectIntegrinas
dc.titleControl of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions
dc.typeArticle


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