Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges

dc.creatorBastos, Viviane A.
dc.creatorGomes Neto, Francisco
dc.creatorPerales, Jonas
dc.creatorFerreira, Ana Gisele C. Neves
dc.creatorValente, Richard H.
dc.date2017-03-09T16:04:50Z
dc.date2017-03-09T16:04:50Z
dc.date2016
dc.date.accessioned2023-09-26T20:10:08Z
dc.date.available2023-09-26T20:10:08Z
dc.identifierBASTOS, Viviane A. et al. Natural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges. Toxins, v.8, n.9, 250, 20p, 2016.
dc.identifier2072-6651
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/17992
dc.identifier10.3390/toxins8090250
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850272
dc.descriptionThe research on natural snake venom metalloendopeptidase inhibitors (SVMPIs) began in the 18th century with the pioneering work of Fontana on the resistance that vipers exhibited to their own venom. During the past 40 years, SVMPIs have been isolated mainly from the sera of resistant animals, and characterized to different extents. They are acidic oligomeric glycoproteins that remain biologically active over a wide range of pH and temperature values. Based on primary structure determination, mammalian plasmatic SVMPIs are classified as members of the immunoglobulin (Ig) supergene protein family, while the one isolated from muscle belongs to the ficolin/opsonin P35 family. On the other hand, SVMPIs from snake plasma have been placed in the cystatin superfamily. These natural antitoxins constitute the first line of defense against snake venoms, inhibiting the catalytic activities of snake venom metalloendopeptidases through the establishment of high-affinity, non-covalent interactions. This review presents a historical account of the field of natural resistance, summarizing its main discoveries and current challenges, which are mostly related to the limitations that preclude three-dimensional structural determinations of these inhibitors using "gold-standard" methods; perspectives on how to circumvent such limitations are presented. Potential applications of these SVMPIs in medicine are also highlighted.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectModelagem
dc.subjectEspectrometria de Massas
dc.subjectImunidade natural
dc.subjectInibidor da metalloendopeptidase
dc.subjectResistência natural
dc.subjectveneno de cobra
dc.subjectcross-linking; hydrogen/deuterium exchange
dc.subjectmass spectrometry
dc.subjectmetalloendopeptidase inhibitor
dc.subjectmodeling
dc.subjectnatural immunity
dc.subjectnatural resistance
dc.subjectsnake venom
dc.subjectstructure
dc.subjecttherapeutic application
dc.titleNatural Inhibitors of Snake Venom Metalloendopeptidases: History and Current Challenges
dc.typeArticle


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