Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil

dc.creatorPena, Geórgia das Graças
dc.creatorDutra, Miriam Santos
dc.creatorOliveira, Andréa Gazzinelli Corrêa de
dc.creatorOliveira, Rodrigo Corrêa de
dc.creatorMelendez, Gustavo Velasquez
dc.date2015-02-04T16:55:30Z
dc.date2015-02-04T16:55:30Z
dc.date2014
dc.date.accessioned2023-09-26T20:10:07Z
dc.date.available2023-09-26T20:10:07Z
dc.identifierPENA, Geórgia das Graças et al. Heritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil. Ann Hum Genet, v. 78, n. 1, p. 40-9, 2014.
dc.identifier0003-4800
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9431
dc.identifier10.1111/ahg.12047.
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850263
dc.descriptionWe aimed to estimate the heritability and genetic correlation between glucose homeostasis and adiposity traits in a population in a rural community in Brazil. The Jequitinhonha Community Family Study cohort consists of subjects aged ≥18 years residing in rural areas in Brazil. The data on the following traits were assembled for 280 individuals (51.7% women): body mass index (BMI), body fat percentage, waist and mid-upper arm circumferences, triceps skinfold, conicity index, insulin, glucose, high-density lipoprotein cholesterol (HDLc), triglycerides and C-reactive protein. Extended pedigrees were constructed up to the third generation of individuals using the data management software PEDSYS. The heritability and genetic correlations were estimated using a variance component method. The age- and sex-adjusted heritability values estimated for insulin (h(2) = 52%), glucose (h(2) = 51%), HDLc (h(2) = 58%), and waist circumference (WC; h(2) = 49%) were high. Significantly adjusted genetic correlations were observed between insulin paired with each of the following phenotypes; (BMI; ρg = 0.48), WC (ρg = 0.47) and HDLc (ρg = -0.47). The homeostasis model assessment of insulin resistance (HOMA-IR) was genetically correlated with BMI (ρg = 0.53) and HDLc (ρg = -0.58). The adjusted genetic correlations between traits were consistently higher compared with the environmental correlations. In conclusion, glucose metabolism and adiposity traits are highly heritable and share common genetic effects with body adiposity traits.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley-Blackwell
dc.rightsopen access
dc.subjectAdiposity/genetics
dc.subjectCross-Sectional Studies
dc.subjectGene-Environment Interaction
dc.subjectObesity/genetics
dc.subjectQuantitative Trait, Heritable
dc.subjectRural Population
dc.titleHeritability of phenotypes associated with glucose homeostasis and adiposity in a rural area of Brazil
dc.typeArticle


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