Potentiation of the activity of antibiotics against ATCC and MDR bacterial strains with (+)-α-pinene and (-)-borneol

dc.creatorSampaio, Nadghia F. Leite
dc.creatorGondim, Cicera N. F. L
dc.creatorMartins, Rachel A. A
dc.creatorSiyadatpanah, Abolghasem
dc.creatorNorouzi, Roghayeh
dc.creatorKim, Bonglee
dc.creatorSouza, Celestina E. Sobral
dc.creatorGondim, Gonçalo E. C
dc.creatorRibeiro Filho, Jaime
dc.creatorCoutinho, Henrique D. M
dc.date2022-09-29T14:23:34Z
dc.date2022-09-29T14:23:34Z
dc.date2022
dc.date.accessioned2023-09-26T20:10:02Z
dc.date.available2023-09-26T20:10:02Z
dc.identifierSAMPAIO, Nadghia F. Leite et al. Potentiation of the Activity of Antibiotics against ATCC and MDR Bacterial Strains with (+)-α-Pinene and (-)-Borneol. BioMed Research International, p. 1-10, 2022.
dc.identifier2314-6141
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/54931
dc.identifier10.1155/2022/8217380
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850219
dc.descriptionMinistério da Educação. Fundação Nacional de Pesquisa da Coréia. Governo coreano (MSIT).
dc.descriptionThe increasing rates of antimicrobial resistance have demanded the development of new drugs as conventional antibiotics have become significantly less effective. Evidence has identified a variety of phytocompounds with the potential to be used in the combat of infections caused by multidrug-resistant (MDR) bacteria. Considering the verification that terpenes are promising antibacterial compounds, the present research aimed to evaluate the antibacterial and antibiotic-modulating activity of (+)-α-pinene and (-)-borneol against MDR bacterial strains. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of the compounds and antibiotics and further evaluate the intrinsic and associated antibiotic activity. These analyses revealed that (+)-α-pinene showed significant antibacterial activity only against E. coli (), while no significant inhibition of S. aureus and P. aeruginosa growth was observed (). However, when combined with antibiotics, this compound induced a significant improvement in the activity of conventional antibiotics, as observed for ciprofloxacin, amikacin, and gentamicin against Staphylococcus aureus, as well as for amikacin and gentamicin against Escherichia coli, and amikacin against Pseudomonas aeruginosa. On the other hand, (-)-borneol was found to inhibit the growth of E. coli and enhance the antibiotic activity of ciprofloxacin and gentamicin against S. aureus. The present findings indicate that (+)-α-pinene and (-)-borneol are phytocompounds with the potential to be used in the combat of antibacterial resistance.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi
dc.rightsopen access
dc.subjectAnti-Bacterial Agents
dc.subjectAntibacterianos
dc.subjectCepas Bacteriana
dc.subjectATCC
dc.subjectMDR
dc.subjectResistência antimicrobiana
dc.subjectAnti-bacterial
dc.subjectbacterial strains
dc.subjectATCC
dc.subjectMDR
dc.subjectAntimicrobial resistance
dc.subjectAntibacterianos
dc.subjectBactérias
dc.titlePotentiation of the activity of antibiotics against ATCC and MDR bacterial strains with (+)-α-pinene and (-)-borneol
dc.typeArticle


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