Morphology of chronic collagen resorption. A study on the late stages of schistosomal granuloma involution.

dc.creatorAndrade, Zilton de Araújo
dc.creatorGrimaud, Jean Alexis
dc.date2012-10-23T20:39:06Z
dc.date2012-10-23T20:39:06Z
dc.date1988
dc.date.accessioned2023-09-26T20:09:57Z
dc.date.available2023-09-26T20:09:57Z
dc.identifierANDRADE, Z. A.; GRIMAUD, J. A. Morphology of chronic collagen resorption. A study on the late stages of schistosomal granuloma involution. American Journal of Pathology, v. 132, n. 2, p. 389-99, aug. 1988.
dc.identifier0002-9440
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5728
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850181
dc.descriptionHepatic periovular schistosomal granulomas produced in mice with 50 cercariae per 10 weeks of infection were seen to involute following curative treatment of schistosomiasis. Residual scars remained, however, and the collagen tissue in them presented morphologic evidence of a slow, progressive degradation that lead to the almost complete disappearance of the lesions 4.5 months after chemotherapy. Ultrastructural changes indicative of collagen degradation were represented by focal lytic dissolution of collagen fibrils and/or by the transformation of such fibrils into a granular electron dense material, a picture different from that seen in more acute models of collagen resorption. In older, involuting granulomas, both type I and III collagens were found up to the end of the resorption process. The immunofluorescence staining for procollagen III and fibronectin correlated with collagen synthesis and the amount of both decreased as the granulomas involuted. Antibodies to CB-peptide (a2 CB3,5 from type I collagen) appeared as a good marker of acute collagen degradation only. Laminin and collagen type IV were absent from the granulomas. Periportal fibrosis produced in mice with 30 cercariae per 20 weeks of infection also presented progressive degradation of collagen 2 and 3 months following curative treatment of schistosomiasis. Present findings suggest that there is not an irreversible fibrotic stage in murine schistosomiasis, that chronic collagen resorption presents peculiar ultrastructural features, that the genetic collagen types are not differentially removed, and that periportal fibrosis in schistosomiasis undergo degradation in a way after specific treatment similar to periovular granulomas.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectColágeno/metabolismo
dc.subjectGranuloma/metabolismo
dc.subjectHepatopatias Parasitárias/metabolismo
dc.subjectEsquistossomose/metabolismo
dc.subjectAbsorção
dc.subjectAnimais
dc.subjectFeminino
dc.subjectGranuloma/parasitologia
dc.subjectGranuloma/patologia
dc.subjectHepatopatias Parasitárias/parasitologia
dc.subjectHepatopatias Parasitárias/patologia
dc.subjectMasculino
dc.subjectCamundongos
dc.subjectMicroscopia Eletrônica
dc.subjectMicroscopia de Fluorescência
dc.subjectEsquistossomose/parasitologia
dc.subjectEsquistossomose/patologia
dc.subjectFatores de Tempo
dc.titleMorphology of chronic collagen resorption. A study on the late stages of schistosomal granuloma involution.
dc.typeArticle


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