Activity of a paromomycin hydrophilic formulation for topical treatment of infections by Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis

dc.creatorGonçalves, Gisele Santos
dc.creatorFernandes, Ana Paula
dc.creatorSouza, Renata Celi Carvalho
dc.creatorCardoso, Jarbas Eustaquio
dc.creatorSilva, Fernanda de Oliveira
dc.creatorMaciel, Fabiana Cristina
dc.creatorRabello, Ana Lúcia Teles
dc.creatorFerreira, Lucas Antonio Miranda
dc.date2013-08-05T17:36:26Z
dc.date2013-08-05T17:36:26Z
dc.date2005
dc.date.accessioned2023-09-26T20:09:38Z
dc.date.available2023-09-26T20:09:38Z
dc.identifierGONÇALVES, Gisele Santos et al. Activity of a paromomycin hydrophilic formulation for topical treatment of infections by Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis. Acta Trop., v. 93, n. 2, p. 161-167, Feb. 2005.
dc.identifier0001-706X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6750
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8850052
dc.descriptionStudies on in vitro skin permeation and in vivo anti-leishmanial activity in mice experimentally infected with Leishmania (Leishmania) majorpointed out to the potential of a new paromomycin (PA) formulation (hydrophilic gel) for treatment of cutaneous leishmaniasis (CL). In this study, the activity of this formulation was evaluated in animals experimentally infected by Leishmaniaspecies that prevail in the New World. PA gel activity was compared to antimony treatment, since it is still the first choice treatment to the different clinical forms of leishmaniasis. The topical treatment activity with 10% PA gel in BALB/c mice infected by Leishmania(Leishmania)amazonensiswas higher than that observed for parenteral antimony treatment, while the efficacy of these two regimes in hamsters infected byLeishmania(Viannia)braziliensiswas similar. These results suggest that this formulation could be suitable for clinical studies and may represent an alternative novel formulation for topical treatment of CL.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectCutaneous leishmaniasis
dc.subjectAmerican tegumentary leishmaniasis
dc.subjectTopical treatment
dc.subjectParomomycin
dc.subjectHydrophilic formulation
dc.subjectLeishmaniasis
dc.titleActivity of a paromomycin hydrophilic formulation for topical treatment of infections by Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis
dc.typeArticle


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