Giardia lamblia: a report of drug effects under cell differentiation

dc.creatorHausen, Moema A.
dc.creatorOliveira, Richard Pereira de
dc.creatorGadelha, Ana Paula Rocha
dc.creatorCampanati, Loraine
dc.creatorCarvalho, Jorge José de
dc.creatorCarvalho, Laís de
dc.creatorBarbosa, Helene Santos
dc.date2019-01-17T12:41:53Z
dc.date2019-01-17T12:41:53Z
dc.date2009
dc.date.accessioned2023-09-26T20:09:07Z
dc.date.available2023-09-26T20:09:07Z
dc.identifierHAUSEN, Moema A. et al. Giardia lamblia: a report of drug effects under cell differentiation. Parasitol Res., v. 105, p. 789-796, May 2009.
dc.identifier0932-0113
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31101
dc.identifier10.1007/s00436-009-1463-4
dc.identifier1432-1955
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8849814
dc.descriptionThe Giardia lamblia life cycle is characterized by two phases during which two major cell differentiation processes take place: encystation and excystation. During encystation, the trophozoites transform into cysts, the resistance form. Once ingested by a susceptible host, the cysts are stimulated to excyst in the stomach, and the excysted trophozoites adhere to the epithelium of the upper small intestine. Our work analyses the effects of four benzimidazole derivatives during Giardia differentiation into cysts and evaluates the excystation efficiency of water resistant cysts. Albendazole (AB) showed the most significant results by inhibiting encystation about 30% and a decreasing rate of excystation efficiency. The ultrastructural organization of the cyst adhesive disk was notably affected by AB treatment. Although other benzimidazoles showed some effect on encystation, they were not able to inhibit the excystation process. It is known that the benzimidazoles affect the cytoskeleton of many organisms but how it interferes in Giardia differentiation processes is our main focus. The importance of studying Giardia's differentiation under drug action is reinforced by the following arguments: (1) Cysts eliminated by hosts undergoing treatment could still be potentially infective; (2) once the host has been treated, it would be desirable that the shedding of cysts into the environment is avoided; (3) the prevention of Giardia dissemination is a question of extreme importance mainly in underdeveloped countries, where poor sanitary conditions are related to high rates of giardiasis. This report concerns the importance of keeping the environment free from infective cysts and on Giardia's drug resistance and differentiating abilities.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer Verlag (Germany)
dc.rightsrestricted access
dc.subjectGiardia lamblia:
dc.subjectEfeitos de drogas
dc.subjectDiferenciação celular
dc.subjectGiardia lamblia:
dc.subjectDrug effects
dc.subjectCell differentiation
dc.titleGiardia lamblia: a report of drug effects under cell differentiation
dc.typeArticle


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