Visceral adiposity is associated with cytokines and decrease in lung function in women with persistent asthma

dc.creatorCapelo, A. V.
dc.creatorFonseca, V. M. da
dc.creatorPeixoto, M. V. M.
dc.creatorCarvalho, S. R. de
dc.creatorAzevedo, C. M.
dc.creatorElsas, M. I. G.
dc.creatorMarques, B.
dc.date2020-02-17T20:11:50Z
dc.date2020-02-17T20:11:50Z
dc.date2016
dc.date.accessioned2023-09-26T20:09:02Z
dc.date.available2023-09-26T20:09:02Z
dc.identifierCAPELO, A. V. et al. Visceral adiposity is associated with cytokines and decrease in lung function in women with persistent asthma. Revista Portuguesa de Pneumologia, v. 22, n. 5, p. 255-261, 29 Mar. 2016.
dc.identifier2173-5115
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/40028
dc.identifier10.1016/j.rppnen.2016.02.005
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8849777
dc.descriptionAbdominal obesity is associated with a risk of cardiovascular diseases, metabolic syndrome and decreased lung function. However, it is not known whether asthma control is influenced by the accumulation of adipose tissue in the various abdominal compartments. OBJECTIVE: To determine associations among abdominal adiposity distribution, asthma control, lung function and cytokines in women. METHODS AND DESIGN: In this cross-sectional study of asthmatic women, data on demographic variables, comorbid conditions, disease history, anthropometric and spirometric measurements were collected. Subcutaneous (SAT) and visceral (VAT) adipose tissues were measured by ultrasound, and the steatosis level was obtained. Asthma control was assessed according to Global Initiative for Asthma (GINA) criteria. Atopy was defined on the basis of allergen-specific Immunoglobulin E and/or skin prick testing. Cytokine levels were determined using enzyme-linked immunosorbant assays (ELISAs). RESULTS: Eighty-three asthmatic women were included, 37% of whom had uncontrolled asthma. After controlling for variables, a negative association between asthma control and VAT and the VAT/SAT ratio was observed. VAT was negatively associated with respiratory parameters after controlling for explanatory variables. In an adjusted model, body mass index (BMI) and SAT were inversely associated with the adiponectin serum level and VAT was associated with the interleukin 6 level. In conclusion, visceral obesity was negatively associated with asthma control and lung function; and positively associated with increased levels of interleukin 6 in women. We hypothesize that women should be studied as a separate group, and we suggest further studies with a control group to know if the uncontrolled asthmatic group is directly affected by visceral adipose inflammatory markers.
dc.description2200-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier España
dc.rightsrestricted access
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAsthma/blood
dc.subjectAsthma/physiopathology
dc.subjectAsthma/therapy
dc.subjectCross-Sectional Studies
dc.subjectHumans
dc.subjectIntra-Abdominal Fat/diagnostic imaging
dc.subjectMiddle Aged
dc.subjectUltrasonography
dc.subjectYoung Adult
dc.subjectAbdominal obesity
dc.subjectAsthma
dc.subjectAsthma control
dc.subjectCytokines
dc.subjectLung function
dc.subjectWoman
dc.subjectCytokines/blood
dc.subjectFemale
dc.titleVisceral adiposity is associated with cytokines and decrease in lung function in women with persistent asthma
dc.typeArticle


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