Mannan-binding lectin enhances susceptibility to visceral leishmaniasis

dc.creatorSantos, Isabel Kinney Ferreira de Miranda
dc.creatorCosta, Carlos Henrique Nery
dc.creatorKrieger, Henrique
dc.creatorFeitosa, Marly Furlan
dc.creatorZurakowski, David
dc.creatorFardin, Babak
dc.creatorGomes, Regis Bernardo Brandim
dc.creatorWeiner, Debra L
dc.creatorHarn, Donald A
dc.creatorEzekowitz, R Alan B
dc.creatorEpstein, Judith E
dc.date2018-06-29T13:29:28Z
dc.date2018-06-29T13:29:28Z
dc.date2001
dc.date.accessioned2023-09-26T20:08:48Z
dc.date.available2023-09-26T20:08:48Z
dc.identifierSANTOS, I. K. F. M. et. Mannan-Binding Lectin Enhances Susceptibility to Visceral Leishmaniasis. Infection and Immunity, p. 5212–5215, 2001.
dc.identifier0019-9567
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27188
dc.identifier10.1128/IAI.69.8.5212-5215.2001
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8849670
dc.descriptionGomes, Regis Bernardo Brandim. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq (grant 20.1145/95-2 to I.K.F.D.M.S.), World Health Organization (grant M8/181/4/C.256 to C.H.N.C.), Pediatric Scientist Development Program (NICHD grant K12-HD00850 to J.E.E.), and the National Institutes of Health.
dc.descriptionLevels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonized Leishmania chagasi promastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonized parasites. Our findings indicate that MBL can modulate the clinical outcome of infection with L. chagasi and the function of infected macrophages.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society for Microbiology
dc.rightsopen access
dc.subjectLeishmaniose visceral
dc.subjectLeishmania chagasi
dc.subjectMonócitos
dc.subjectMacrófagos
dc.subjectInfecção
dc.subjectVisceral Leishmaniasis
dc.subjectLeishmaniasis chagasi
dc.subjectMonocytes
dc.subjectMacrophages
dc.subjectInfection
dc.titleMannan-binding lectin enhances susceptibility to visceral leishmaniasis
dc.typeArticle


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